Advantages of Eliquis or Xarelto over Coumadin?

Posted by lgerkin @lgerkin, Feb 3 1:18pm

Hi – I've been on Coumadin for 15 years and my PCP and hematologist suggested I might want to try the newer generation of blood thinners. So, I started taking Eliquis last week. I haven't noticed any changes but it does make me nervous that there is no way to know for sure if my INR is at the proper level. I realize that not having to get tested once a month is great in terms of convenience and I like that I don't have to avoid foods with Vitamin K. My question is – are there other benefits to taking Eliquis over Coumadin? The higher cost isn't too much of an issue since the copay isn't too bad with my insurance.

@lgerkin, I have no experience with taking blood thinners but I thought I would share the following articles that may provide more information for you while we wait for other members to share their experience. @predictable may also have some thoughts or information on blood thinners.

– (2019) Are the new blood thinners better than warfarin (Coumadin)?: https://www.health.harvard.edu/heart-health/are-the-new-blood-thinners-better-than-warfarin-coumadin
– (2017) Mayo Clinic Minute: Research shows newer blood thinners have lower risk of kidney function decline: https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-research-shows-newer-blood-thinners-have-lower-risk-of-kidney-function-decline/

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@johnbishop

@lgerkin, I have no experience with taking blood thinners but I thought I would share the following articles that may provide more information for you while we wait for other members to share their experience. @predictable may also have some thoughts or information on blood thinners.

– (2019) Are the new blood thinners better than warfarin (Coumadin)?: https://www.health.harvard.edu/heart-health/are-the-new-blood-thinners-better-than-warfarin-coumadin
– (2017) Mayo Clinic Minute: Research shows newer blood thinners have lower risk of kidney function decline: https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-research-shows-newer-blood-thinners-have-lower-risk-of-kidney-function-decline/

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Thank you for the info! I'll definitely check it out.

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Absolutely essential: read everything you can find about Elequis, especially the maker’s package insert. U think it comes with an FDA black box warning. It is not a drug to mess around with, but it looks to be better than Warfarin (BTW: Warfarin is diluted rat poison).

There is less risk of serious bleeding with Elequis & Xarelto. However, at least some of that evidence comes from meta-analysis which is not a very valid statistical procedure. The inventor of meta-analysis used to work for me, and he refused to use it because he didn’t trust it. There is a very costly way to stop internal bleeding from Elequis but not Xarelto. Do not do anything that might increase the risk of internal bleeding. That includes no aspirin, no NSAIDs. Blood has 2 different clotting systems, one for little cuts and bruises, and an additional system fro big cuts. The newer drugs only affect the big cut clotting system because that is what makes dangerous blood clots.

IF you get a cut that bleeds for more than 15 minutes, check with your MD right away because you may need a trip to the ER to stop it. Or you can do what the ER will charge $1,100 to do– slap Combat Gauze on it. I asked the ER MD what Combat Gauze was. He gave me some chemistry mumbo jumbo. He got a funny look on his face when I replied “That’s a napkin soaked in powdered kitty litter”. High quality kitty litter costs less that $1 a lb. Wait till you see what Combat Gauze costs, but I keep it handy, and it is a lot cheaper than the ER. I’ve only had to use it once at home, so far.

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I’ve recently been diagnosed with AFib and Dr has me on Eliquis (30 day free sample) and Metoprolol. Just checking drug prices for blood thinners took my breath away. Are these new drugs worth it or are there less expensive options that work just as well? I will be having discussion about this with cardiologist tomorrow, so looking for some input. Thanks

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@abbysmom

I’ve recently been diagnosed with AFib and Dr has me on Eliquis (30 day free sample) and Metoprolol. Just checking drug prices for blood thinners took my breath away. Are these new drugs worth it or are there less expensive options that work just as well? I will be having discussion about this with cardiologist tomorrow, so looking for some input. Thanks

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@abbysmom. I'm on Xeralto, same type of blood thinner. They are very expensive, even with insurance. Wafarin is cheaper but it interacts with vitamin k… No green leafy vegetables and other food high in this vitamin. Ieat alot of green vegetables so I refill it monthly so it's not such a sticker shock. Last year I had a Co pay of over 100 a month. I called the drug company for assistance but don't qualify. You can try and see if you have better luck. My cardiologist was able to give me some samples. That's another way. I do not have afib but I had a TIA so I have to take it so I don't have a stroke. Take care. Please share what your doctor say.

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Hi @abbysmom and welcome to Mayo Clinic Connect. So glad you joined the conversation. As you will see I paired your question with a discussion surrounding these drugs so that you can connect with members that are already talking about them.

Here is a website so that you can compare and contrast anticoagulants – https://www.goodrx.com/anticoagulants

I would definitely ask your cardiologist what he/she recommends. Have you researched one that you like over the other, whether price or side effects etc.?

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