T3b Prostate Cancer with Seminal Vesicle Invasion

I looked further through the pile of papers I reviewed after my surgery, and found another related to this question. They conclude "...The frequency of BCR was 33.9% in cases with combined EPE [extraprostatic extension] and SVI [seminal vesicle invasion] versus 12.5% in cases with SVI alone..."

This is from 2020, Houston Methodist/Cornell University Medical College:
https://pubmed.ncbi.nlm.nih.gov/32956915/

Thank you. This is one I had not seen. I appreciate any info I can locate. Even Dr. Walsh's book has very little to say regarding SVI

My inquiry on T3b Seminal Vesical Invasion wasn't on the main board for long. Wondering if any new viewings on the subject, prognosis, personal experience with it, etc? Happy and Healthy New Year to all.

I had the same diagnosis 23 years ago. I’ve had several recurrences since, radiation treatments and hormone therapy. Two years ago I got a PSMA PET scan which showed four cancerous pelvic lymph nodes only. I had them radiated and went on Nubeqa for 24 months, which ends day after tomorrow. My current PSA is < 0.008. I’m hoping it stays that way. Whatever treatment you consider get the best scan you can get and be as aggressive as you can to kill whatever cancer you may have. Good luck. You have lots of company.

My Gleason was 4+5=9. Grade T3b. Had RP 3.9.22. Followed by 39 rounds of radiation which ended 1.13.23. So far all quarterly PSA tests have been < 0.01. So far so good.

Sounds like you have the right medical care. Good for you! Happy New Year.

My Gleason was 4+4. Involement of seminal vesicals, bladder neck, lymph nodes. Doc said surgery was not an option. I was put on Zoladex and Abiraterone for 3 months and then IMRT (Tomotheraphy) 20 factions in Jan-Feb last year. My PSA has been around 0.03 for the last few months.

It’s now been nearly a year since I went off all treatments. PSA remains < 0.008. Undetectable. Tips from my experience: Stay vigilant, monitor PSA at regular intervals, if PSA rises, get the most sensitive scan you can, and treat when appropriate, not forgetting radiation, which is not your granddad’s variety. It’s much improved. Don’t rush into treatment. Above all remain hopeful. Best wishes.

I had diagnosis of poorly differentiated seminal vesicle and prostate Gleason score of 7 had radical prostectomy and removal 5.5 centimeter tumor August 2025 negative margins against bladder and radical prostatectomy and pelvic lymphadenectomy, for poorly differentiated carcinoma, predominantly involving the right seminal vesicle and focal infiltration of the prostate. A single right pelvic LN positive for metastasis. All of the 8 left pelvic nodes were negative I completed radiation of the prostate bed. In October 2024 scan in May was negative will be back in September for another fingers crossed.

I think I can learn a lot from this group given my recent prostate cancer diagnosis. I am a 72 years old (otherwise healthy) man who just found out that the pathology report of my recent prostate surgery identified a PTNM stage cancer. Details include Gleason 3+4, with two concurrent adverse factors: SVI and PNI involvement although the one lymph node they tested was negative. Other things I consider as adverse factors are: pre-surgery PSA of 14.5 and a GPS score of 47.

I have my first appointment with my surgeon next Tuesday. Given my cancer profile, what options are available for me as next steps? Immediate treatment or watch PSA trajectory before starting treatment ?
I understand my PTNM stage cancer plus 2 concurrent adverse factors puts me very high risk groups of biochemical recurrence? What is the average time for recurrence? What is the life expectancy of people with such profile (the average and most probable, not the outlier)? What is life like moving forward for me?

Lots and lots of questions swirling in my head. Any answer based on your own experience and/or research is welcome.