Anyone using Amitriptyline HCL for Neuropathy instead of Gaba or Lyric

Posted by madmouse43 @madmouse43, Nov 22, 2023

A doctor has prescribed Amitriptyline HCL for my Neurapathy pain in my feet instead of Gaba or Lyrica. Does anyone have any experience with this. Like all thye others the side effects are many and can be serious (I realize that drug companys have to put any possible adverse effect in their drug instructions even if it only "smells funny"). But I am intereseted in real world situations before I start to take this med.

Interested in more discussions like this? Go to the Neuropathy Support Group.

@madmouse43

I appreciate the information. So far I have been lucky that my PN only very rarely effects my sleep. I take a 10mg Melatonin gummy which helps me get to sleep. I am at the very beginning of this med regiment. Frankly the side effects posted for all three of these (Gabapentin, Lyrica and Amitriptyline) along with sometime questionable effectiveness cause me concern .

Jump to this post

@madmouse43 Understandable. I’m glad to hear the PN isn’t interfering with your sleep! I haven’t found anything to help enough to justify the side effects (with the exception of Amitriptyline, but to your point, whether it actually helps SFN is questionable). I must caution against using Lyrica. It caused a bout of despair that I have never experienced before. Thankfully I was able to recognize that it was a side effect from the medication and stopped immediately but it was scary. However, I know some people use it with no issues. Everyone is different. I have found some relief in my PEMF therapy mat. Have you tried things other than prescriptions?

REPLY

I had similar concerns about the oral medications for peripheral neuropathy and their side effects. I'm now able to control the nerve pain in my feet by using 5% lidocaine patches, which are available by prescription. I cut them into strips and place them on the tops of my feet where the epidermis is thinner to allow better absorption of the drug. Mayo now lists the patches on their website as a treatment for the pain of peripheral neuropathy.

REPLY
@madmouse43

I appreciate the information. So far I have been lucky that my PN only very rarely effects my sleep. I take a 10mg Melatonin gummy which helps me get to sleep. I am at the very beginning of this med regiment. Frankly the side effects posted for all three of these (Gabapentin, Lyrica and Amitriptyline) along with sometime questionable effectiveness cause me concern .

Jump to this post

I have been on Amitriptyline for almost thirty years. I started with 5mg and worked up to 50mg to ease the pain after two spinal operations, which left me with four rods and screws. I had crushed L1. The Amitriptyline gives me a good night's sleep, but sadly it doesn't ease my neuropathic pain in my feet.

REPLY
@boltz7555

@madmouse43 Understandable. I’m glad to hear the PN isn’t interfering with your sleep! I haven’t found anything to help enough to justify the side effects (with the exception of Amitriptyline, but to your point, whether it actually helps SFN is questionable). I must caution against using Lyrica. It caused a bout of despair that I have never experienced before. Thankfully I was able to recognize that it was a side effect from the medication and stopped immediately but it was scary. However, I know some people use it with no issues. Everyone is different. I have found some relief in my PEMF therapy mat. Have you tried things other than prescriptions?

Jump to this post

I have tried other things. I tried the Revitive machine that O got 2 years ago. I thought it helped. This time I used it consistently for 2 weeks and noticed no help at all. I tried Alpha-Linolic-acid (ALA) with very marginal results (600mg 2 times a day). I am still taking the ALA as my PCP told me that is is helpful for other issues and takes it herself (Reading the results that some people have was looking promising.) I mentioned in another post that the same PCP thought that some of it might be low blood pressure do what I was doing when it came on. Reduced my heart meds with my Cardiologist and PCP and that helped quite a bit for me, but I realize that was a personal unique result.
I have tried compression socks and numerous creams. Lidocaine 4% has helped (I like this as I found it in a roll-on so I don't contaminate my hands with it and het it in my eyes, etc.)
The bottom line, for me, is that I have tried a lot of different remedies with very little or marginal success.

REPLY
@kd59

Im on lyrica for nerve pains. When it wasn’t lasting every six hrs, nortryptilline was rxd hoping it would have a synergistic effect for nerve pains.
Yrs ago amytripptilline was ineffective on its own. A pharmacist specialist suggested nortryptilline in tangent. Just after a month it’s presently working!

Jump to this post

Does it help with the horrible tingling and burning feet both??

REPLY
@julbpat

I was on Gabapentin, then Lyrica. I switched to Tegretol and it works much better for my burning pain, with no drowsiness or brain fog (for me). I am on a pretty high dose now - 400 mg am, 600 mg pm.

Jump to this post

Did you have the horrible tingling in your legs also?

REPLY
@bettyg81pain

Did you have the horrible tingling in your legs also?

Jump to this post

No just my toes

REPLY
@bettyg81pain

Did you have the horrible tingling in your legs also?

Jump to this post

I have pain. My toes burn but not my legs. Tegretol greatly minimizes that burning.

REPLY

I went from 10mg Amitryptyline to 25mg. Got tachycardia. Raised pulse.
Had to stop .

REPLY
@bettyg81pain

Does it help with the horrible tingling and burning feet both??

Jump to this post

What might be horrible to you, might not be to me ,as we’re all different.
I have discomfort, burning, numbness, tingling, pangs etc of different levels. Not always at the same time. My spinal stenosis causes the sensation continuously.
I also have SFN which is common with my underlying condition hEDS.
Im going to try some new supplements that sound promising.
https://www.frontiersin.org/articles/10.3389/fpain.2023.1114428

REPLY
Please sign in or register to post a reply.