Hi @mala1921 and welcome to Mayo Clinic Connect. You'll notice that I moved your message to this existing discussion called "Trying to recover from a c. diff infection (Clostridium difficile)." I did this to better connect you with other members talking about C-diff like @sandyabbey @pines @virgo1952 @femalegolfer @ngorman25 @pibacher and others.

You may also be interested in this discussion where several members talk about taking Flagyl.
- C. difficile – Are your guts ever normal again? https://connect.mayoclinic.org/discussion/c-difficile-are-your-guts-ever-normal-again/

Mala, How long have you been taking Flaygl? How is it working for you?

@mala1921 I too took clindamycin for a tooth infection back in August, 2018. Three weeks later I ended up in the hospital for 8 days. Agony! They gave me vancomycin but I relapsed 4 times over the next 7 months. Lost 14 pounds and weighed 86 pounds. Finally, I had an fmt (fecal microbiome transplant) in March, 2019. Since then, I have been doing ok. However, I still can't gain any weight back! I live in terror of it coming back or if I get sick and need any antibiotics. A lot of antibiotics can start it back up. I take probiotics every day, specifically, Visbiome and saccharomyces boulardii. If you have any questions, let me know. Good luck to you! Hope you feel better soon.

I took Clindamycin for a sinus infection in 2018. Shortly after taking it, I ended up with Cdiff. I've never been so sick. I was given Flaygl for the first infection. After stopping it, three weeks later Cdiff was back. I then was given Vancomycin (Vanco) for 10 days. Again, the Cdiff returned after a few weeks, I then did the Vanco pulse and tapper method for over a month. After completing that, I was okay for about a month. But then I had a 4th bout of Cdiff. My gastroenterologist said he would prescribe Fidaxamycin (Difficid). It's expensive. $7,000 for 20 pills and the co-pay was almost $1,000. But it worked. My insurance wasn't willing to pay until I had tried Vanco. I wish medical providers would prescribe Difficid after a second round of Cdiff. And many physicians are not even using Flaygl as the first line of defense any longer. They're going right to Vanco. I also know that many dental offices are no longer prescribing Clindaymcin for infections. The rate of Cdiff is peaking after using it. I hope this info is helpful to you. If the Flagyl doesn't work, I would suggest you talk to your physician about Difficid. If it hadn't worked for me, I was going to do a fecal transplant. Just happy it happened to be the one to kill all the Cdiff spores.