Has anyone heard of low dose Naltrexone as a potential treatment?

Did you ever experience insomnia when taking it in the morning? I recently started taking it, .25mg for a week and now I'm on my 4th day at .5mg. The past 3 nights I've had more trouble sleeping than usual. Maybe it's a coincidence since I had insomnia issues before taking LDN. Just wondered what your experience was?

LDN saves my wife's life.
She was in a bad downward spiral to the point of being bed bound. The very next day after her first dose of 1.5mg she walked into the living room!!!!!!
However she is still very sick. Extreme fatigue, tremors and brain fog amongst many other issues
(We are not a Mayo patient, they have not expected us)

I had insomnia occasionally before LDN, but this is more persistent, it was not as severe last night so I’m hopeful that I can get used to the higher dose. I also find that I have stranger dreams. I had to titrate slowly.

I had significant improvement relatively quickly. I went through Ageless rx. I gained a significant amount of energy and cognition. I would say definitely try it. I also typically experience bad side affects but I haven’t on ldn naltrexone.

Naltrexone is prescribed primarily for addiction issues.
It blocks the effects of opioids, alcohol etc.
If you are using low dose sedative to manage your anxiety from your Covid symptoms, Naltrexone will cancel that effect. I know most are very negative to sedative because of it’s addictive nature, however antidepressants are also addictive and hard to finally discontinue. I don’t really see the difference. Very low dose Klonopin has helped me. For this reason I cannot give Naltrexone a try.

I want to add that I have discovered that I absolutely have to take with food. Recently I’ve made the mistake of taking without food and I have had terrible side effects…extreme nausea, shakiness, weird aching…etc

Yes, It has been the most effective treatment of all for me. I needed to titrate slowly, starting at .5mg, then increasing by same every week to 10 days until reaching 4.5 mg. Helped reduce headaches, dizziness and fatigue.

Could you share what your low dose of Klonopin is, and do you take it in the morning or at night? Has it helped with LC fatigue and brain fog or just for LC-related anxiety?

Pills are .5 MG. They are supposed to have a twelve hour effect. To me it feels like Xanax and often puts me to sleep for awhile. I would say, at least for me, no help with brain fog or fatigue, as it is sedating. I take whenever anxiety is high. My dose is up to two per day, but I don’t usually take more than one.

Yes, I have with excellent results!!
My main symptoms were muscle tremors, overall chest pain, radiating nerve pain, overall CNS and ANS dysfunction (rapid heart rate, GI issues, blood pressure swings, dizziness, etc.), extreme fatigue, and difficulty with sleeping. For the pain management and sleep disruption, my PCP started me on a low dose (10mg) of Amitriptyline and a regimen of Low Dose Naltrexone (LDN) with the hopes of resetting my central and autonomic nervous systems - I've been increasing dosage from 1mg to 4mg presently (increasing 1mg every 3 months) and my pain is much improved, I am sleeping well again, and I've had nervous system functioning (heart rate, tremors, muscle spasms, GI issues) almost restored to normal. LDN is higher doses is given to opioid overdose patients with the hopes of resetting their CNS and helping the body to naturally produce endorphins. I hope you find this helpful and please reach out with any questions.