Low dose naltrexone for Post-Covid Recovery experiences?

Naltrexone is prescribed primarily for addiction issues.
It blocks the effects of opioids, alcohol etc.
If you are using low dose sedative to manage your anxiety from your Covid symptoms, Naltrexone will cancel that effect. I know most are very negative to sedative because of it’s addictive nature, however antidepressants are also addictive and hard to finally discontinue. I don’t really see the difference. Very low dose Klonopin has helped me. For this reason I cannot give Naltrexone a try.

I want to add that I have discovered that I absolutely have to take with food. Recently I’ve made the mistake of taking without food and I have had terrible side effects…extreme nausea, shakiness, weird aching…etc

Yes, It has been the most effective treatment of all for me. I needed to titrate slowly, starting at .5mg, then increasing by same every week to 10 days until reaching 4.5 mg. Helped reduce headaches, dizziness and fatigue.

Could you share what your low dose of Klonopin is, and do you take it in the morning or at night? Has it helped with LC fatigue and brain fog or just for LC-related anxiety?

Pills are .5 MG. They are supposed to have a twelve hour effect. To me it feels like Xanax and often puts me to sleep for awhile. I would say, at least for me, no help with brain fog or fatigue, as it is sedating. I take whenever anxiety is high. My dose is up to two per day, but I don’t usually take more than one.

Yes, I have with excellent results!!
My main symptoms were muscle tremors, overall chest pain, radiating nerve pain, overall CNS and ANS dysfunction (rapid heart rate, GI issues, blood pressure swings, dizziness, etc.), extreme fatigue, and difficulty with sleeping. For the pain management and sleep disruption, my PCP started me on a low dose (10mg) of Amitriptyline and a regimen of Low Dose Naltrexone (LDN) with the hopes of resetting my central and autonomic nervous systems - I've been increasing dosage from 1mg to 4mg presently (increasing 1mg every 3 months) and my pain is much improved, I am sleeping well again, and I've had nervous system functioning (heart rate, tremors, muscle spasms, GI issues) almost restored to normal. LDN is higher doses is given to opioid overdose patients with the hopes of resetting their CNS and helping the body to naturally produce endorphins. I hope you find this helpful and please reach out with any questions.

@prancer20 Per your "I start feeling better then increase my activity and that is followed by fatigue." The Mayo Clinic and my personal experience would tell you that you aren't practicing moderation and graded gradual increasing activity and exercise. I was in the same place earlier this year. I would exercise and crash. Once I went to Mayo Rochester all of my reading, listening, and local medical professional visits coalesced into an understanding of using moderation as part of my recovery strategy. I am recovery as a result. I too am tempted on the days I feel good to just let it rip and go do things in the yard or exercise more, bad choice. I will crash and hurt my recovery not help it. Highly recommend getting to Mayo to build your plan. Art

There is not yet a magical pill, including Naltrexone, but individual symptoms (brain fog,etc.)may find it helpful. No cures, only coping strategies. These involve monitoring your daily habits to avoid Rollercoaster behavior.

What type of physician prescribed it for you? Was it a Mayo physician?

@prancer20, yes on both. Went to Mayo Rochester in August and am now on Cymbalta and Naltrexone by their program. These two scrips, many supplements, and 'the plan' we put together have my symptoms breaking up and I look forward by years end to this all being history. Highly recommend Mayo. I am on Medicare A and B total cost has been ~$300 not including travel of course.