Low dose naltrexone is often discussed in the Post COVID Recovery support group. You may also be interested in these related discussions:
- Anyone taking Naltrexone for Long COVID?
https://connect.mayoclinic.org/discussion/anyone-taking-naltrexone-for-long-covid/
- Low dose naltrexone for Post-Covid Recovery experiences?
https://connect.mayoclinic.org/discussion/low-dose-naltrexone-for-post-covid-recovery-experiences/
- Any research on low-dose naltrexone?
https://connect.mayoclinic.org/discussion/any-research-on-low-dose-naltrexone/

I have just started taking LDN as I have a long hauler niece back east who has had good results with it....she was lucky enough to get in a long haul clinic so it was prescribed thru them. The recommendation is to titrate with it so I am taking a low dose and will very slowly work up to 4.5 mg.

Yes, low dose Methylene Blue is interesting also.

I have been on LDN for Long Covid as post viral anti inflammatory. It is compounded at a well known pharmacy with high standards on preparation and cleanliness. So far I have not seen any improvement in my pain and I too developed burning in my arms. I am going to try to stick with the LDN though to see if it helps the bigger picture or until I cannot take the burning in my arms anymore. I have only been on the 4.5 mg dose since July 7th, 2023 and have had long covid issues since Oct 2022.

I am trying LDN. I started at 1.5 and then 3.0 for a few months with no noticeable improvement. I do have to take it in the morning to avoid insomnia. I have just recently started 4.5 and am seriously reconsidering it. I find myself taking deep breaths (anxious) and my sleep is horrible, not to mention daily headaches. I know it can take time but not sure it’s worth the trial period. I also take the gummy Coq10, no noticeable difference in my LHC symptoms.

LDN saves my wife's life.
She was in a bad downward spiral to the point of being bed bound. The very next day after her first dose of 1.5mg she walked into the living room!!!!!!
However she is still very sick. Extreme fatigue, tremors and brain fog amongst many other issues
(We are not a Mayo patient, they have not expected us)

I had significant improvement relatively quickly. I went through Ageless rx. I gained a significant amount of energy and cognition. I would say definitely try it. I also typically experience bad side affects but I haven’t on ldn naltrexone.

Naltrexone is prescribed primarily for addiction issues.
It blocks the effects of opioids, alcohol etc.
If you are using low dose sedative to manage your anxiety from your Covid symptoms, Naltrexone will cancel that effect. I know most are very negative to sedative because of it’s addictive nature, however antidepressants are also addictive and hard to finally discontinue. I don’t really see the difference. Very low dose Klonopin has helped me. For this reason I cannot give Naltrexone a try.

Yes, It has been the most effective treatment of all for me. I needed to titrate slowly, starting at .5mg, then increasing by same every week to 10 days until reaching 4.5 mg. Helped reduce headaches, dizziness and fatigue.

Yes, I have with excellent results!!
My main symptoms were muscle tremors, overall chest pain, radiating nerve pain, overall CNS and ANS dysfunction (rapid heart rate, GI issues, blood pressure swings, dizziness, etc.), extreme fatigue, and difficulty with sleeping. For the pain management and sleep disruption, my PCP started me on a low dose (10mg) of Amitriptyline and a regimen of Low Dose Naltrexone (LDN) with the hopes of resetting my central and autonomic nervous systems - I've been increasing dosage from 1mg to 4mg presently (increasing 1mg every 3 months) and my pain is much improved, I am sleeping well again, and I've had nervous system functioning (heart rate, tremors, muscle spasms, GI issues) almost restored to normal. LDN is higher doses is given to opioid overdose patients with the hopes of resetting their CNS and helping the body to naturally produce endorphins. I hope you find this helpful and please reach out with any questions.