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ARINA-1 Clinical Trial with nebulized solution-NO ANTIBIOTICS
GOOD NEWS!!!
We have been asking for bronchiectasis treatments that are not antibiotics, and we have been heard!
Dr. Charles Daley is a well-respected expert from National Jewish Health in Denver. He was a keynote speaker at the World Bronchiectasis Conference and gave the closing remarks.
Dr. Daley is also the principal investigator of a study evaluating ARINA-1, a nebulized solution manufactured by Renovion that has been shown to prevent mucus from clogging our airways. Clogged airways cause inflammation and infection, a cycle we try to break with daily airway clearance and, often, antibiotics.
ARINA-1 is a sterile formulation that is manufactured under strict guidelines. The solution includes glutathione, ascorbic acid, and a buffer to modify the pH.
The trial will measure ARINA-1’s impact on quality of life, mucus viscosity, and inflammation.
Researchers are looking for 25 more participants for the 28-day study. Participants need to be diagnosed with non-CF bronchiectasis and have mucus. In addition to National Jewish in Denver, trial sites are located in Baltimore; Philadelphia; Seattle; Birmingham, AL; New Orleans; Tyler, TX; Winston-Salem, NC; Portland, OR; and Charleston, SC. If you live in or around one of these areas and are interested in the trial, let me know.
Click on the following link to clinicaltrials.gov for more information on the ARINA-1 trial.
https://tinyurl.com/tsh6fjnr
I am working with Renovion and researchers to share this opportunity, and I can help answer basic questions regarding:
-Participating doctors
-Laboratory studies of ARINA-1
-How nebulizing this solution differs from nebulizing glutathione alone or orally administered NAC
-The importance of the combination of glutathione and ascorbic acid
If you have other questions about the trial, the drug or how to enroll, let me know and I can help you get an answer from the Chief Scientific Officer at Renovion who is a great resource.
Most importantly, discuss this trial with your doctor.
Dr. Daley implored us to get involved in bronchiectasis and NTM research. Let’s show him and the researchers working on our behalf that we are willing to participate whenever possible.
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HugInterested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.
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FYI - When I could not longer source Jarrow's NAC, I wrote to them about the scarcity hoping they'd begin making NAC again. Unsolicitedly, they suggested Life Extension brand in case you'd rather a domestic supplier.
https://www.lifeextension.com/search#q=nac&t=coveo4A2453FD
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1 ReactionThis sounds like possibly a game changer!!! I assume it is only in Phase 1 trial stage. So we’re looking at possibly 2-3 yrs before availability on the market. Am I wrong?
I’m sorry my mistake, I see it’s phase 2a. I apologize for my not looking first.
It is a Phase 2a trial with 50 participants. Yes, 2026. Linda
Thank for the link to this trial! I contacted UT Tyler about it earlier this week. I am scheduled to begin the trial in mid-September.
I highly encourage anyone who thinks they may qualify to contact the recruiter for the facility closest to you. The recruiter at UT Tyler has been very patient about answering my questions. Being a part of a trial is a little scary. After much thought and prayer I became convinced that rather than being a victim of this unfortunate condition I need to be a part of helping to find new treatments. I am very excited to see where this leads.
The link in Linda’s original post is very informative. If you have questions I might be able to answer just let me know.
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3 ReactionsThank you for deciding to participate. I know it’s not an easy decision. It is extraordinary to think about all the drugs out there and all the people who stepped up to be in clinical trials. Now you’ll be part of that amazing group. Again thank you! Linda
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1 ReactionI am curious about why being part of a trial is scary not knowing what is involved. The Arina-1 is not a scary drug or antibiotic. Do you have to travel to a location when in a study? Would like to know more.
Sometimes the unknown is scary. Sometimes, if you are stable, you don’t want to disturb that. Also, the purpose of a clinical trial is to determine if there are any potential adverse reactions.
But, at the same time, it’s a wonderful experience to know you are contributing to science and helping to move toward a cure.
Linda
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1 ReactionDo you travel to the location nearest you or how does that work. Can anyone explain?
You would go on clinical trials.gov and find a location nearest you. Each site has a clinical trials coordinator who can answer your questions. You would have to return to the site three times.