Prolia treatment for osteoporosis: What is your experience?

Second opinion doc yesterday said bisphosphonate is not that effective after Prolia. I did not discuss any further because I am not on Prolia but check it out before making a decision. I didn't get details and it is always possible I misunderstood.

Doc yesterday also discussed doing blood test bone markers while switching to a bisphosphonate to make sure timing is right- recommendation is to start bisphosphonate 6 months after ending Prolia, but if too early the bisphosphonate doesn't work and if too late, fractures from ending Prolia can happen.

Neither of my two (top) endos uses Prolia much anymore because you basically have to stay on it, according to the doc yesterday. She prescribes it for those who cannot tolerate anything else and for those who cannot take bisphosphonates due to kidney issues.

I have been treated for O.A. for three years. I can't remember the pills I was on nut had side effects from that. So have now had 2 shots of Prolia.
I am a participant in the 'Canadian Longitudinal Study on Aging' (CLSA) and this week, I was at McMaster for my testing. My height is now 5' 6.5".... my original height was 5' 8.25".... YIKES!
Is this a lot of height loss in just 5 years???
I am going back to my GP, with this info, but wondering how others have found their disease progression.
Thanks for your input!

I agree with @windyshores. In fact, leaving Prolia for "alendronate" is what my endocrinologist at Mayo Clinic instructed me to do. So far....so good since June 13, 2022.

Chris

In February, I had a dexascan after a year on Prolia. My spine improved from -4.1 to -3.6! My doctor was surprised as was I. I have had no side effects. My back feels much better since I had suffered a couple of compression fractures before I started Prolia. I had my 3rd shot the first of March. I know it is helping because my back feels so much better. Before Prolia. I couldn't stand very long in the kitchen and cook. Now I have grandkids over to make baked goodies with grandma! I have read that you can safely take Prolia for 8 years. At that point, I hope to combine it with Forteo or Tymlos for a year to help build bone.

I am 73 and took Prolia 2 times. By the third time I was supposed to take it, I decided not to. I had dermatitis around my lips and a bad shoulder pain. I just stopped it and am fine now! I only have osteopenia not osteoporosis. I now go to a naturopath and she is helping me with my bone health. One of which is to take 2 tblp spoons of black sesame seeds (full of calcium), and Vit D (4000 IU) which I had already been on. Plus get a K vitamin.

@pami transitioning from Prolia to other meds is complex and even problematic. I hope you will talk with an osteoporosis expert on this. Keith McCormick's new book "Great Bones" is a good resource. Also Ben Leder MD at MGH has a great video on combinations and sequencing of meds.

Me too, I have been on Prolia for a few years now, and I have not had any side affects. So far, so good.

I am concerned also, as the side effects seem severe...I would love to hear from anyone taking it and your comments..thank you so much...

@bonnieb the real issue with Prolia is what happens when you stop. You need to go on Reclast or another bisphosphonate, preferably Reclast, or you rapidly lose bone density and increase fracture risk.

Thanks for your quick reply...I would love to know what my other options are...I was on Fosamax 10 yrs ago and improved...now Lumbar Spine and Femoral are -2.7 & - 1.8..can one go back on Fosamax after being off for about 10yrs.? Thank You Much...Bonnie