Can I go on hormone replacement therapy for menopause?
I am heterozygous for Leiden Factor 5, although I haven't had any issues with blood clots so far -I'm 54 yrs old. I'd like to go on hormone replacement therapy (HRT) due to menopause. I've read using an estrogen patch decreases the risk of clots associated with HRT. I'd like to hear if others with Leiden Factor V have used HRT, and if so, if they also went on a blood thinner to further decrease the clotting risk. Thanks!
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Hello @kms1s according to an article from the National Institute of Health/ Pub Med, there is an increase risk in developing blood clots in patients with Leiden Factor 5.
Here’s an Expert from the report, “Results confirmed that all women have a higher risk for the development of venous thrombosis while on HRT. The presence of a genetic mutation, such as factor V Leiden, in combination with HRT dramatically increased an individual's chance for developing venous thrombi”
https://pubmed.ncbi.nlm.nih.gov/14606135/#:~:text=Results%3A%20Results%20confirmed%20that%20all%20women%20have%20a,increased%20an%20individual%27s%20chance%20for%20developing%20venous%20thrombi.
There are several other members in the group who share the similar diagnosis of Leiden Factor 5 but I’ve not found any conversations regarding HRT.
https://connect.mayoclinic.org/discussion/anybody-else-have-factor-2-and-factor-v-leiden/
The best source for finding out what would personally work for you would be checking in with your hematologist. They know your history and may have had this conversation with other patients. Have you talked this over with your hematologist?
Have you considered bio-identical HRT? None of the adverse side effects of standard HRT, although you should absolutely disclose your med Hx with your doc. BHRT is only available from a functional medicine doc, who can further advise if this might be helpful to you.
Yo empecé hace 2 meses. Por el momento sin complicaciones.
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