Hello @kms1s according to an article from the National Institute of Health/ Pub Med, there is an increase risk in developing blood clots in patients with Leiden Factor 5.

Here’s an Expert from the report, “Results confirmed that all women have a higher risk for the development of venous thrombosis while on HRT. The presence of a genetic mutation, such as factor V Leiden, in combination with HRT dramatically increased an individual's chance for developing venous thrombi”
https://pubmed.ncbi.nlm.nih.gov/14606135/.
There are several other members in the group who share the similar diagnosis of Leiden Factor 5 but I’ve not found any conversations regarding HRT.
https://connect.mayoclinic.org/discussion/anybody-else-have-factor-2-and-factor-v-leiden/
The best source for finding out what would personally work for you would be checking in with your hematologist. They know your history and may have had this conversation with other patients. Have you talked this over with your hematologist?