My Experience on Evenity for Treating Osteoporosis

Hello
I just finished my 6th injection. After my injections the last 2 months I have increased burning pain in my knees, and now hands and wrists. I have not had this before the injections. I also notice my hair seems to be thinning. I am active and walk at least 3 miles a day regardless of the knee pain. My doctor has 9 women on Evenity who have had no complaints of joint pain. I asked him if the joint pain would disappear at the end of the 12 months. He could not say and suggested I have a Rheumatologist consult. I would like to know if anyone who has completed their Evenity course had side effects and if they decreased at the end of the course.

@lauratys As always, I want to jump in and say that I am so sorry for these side effects. But also add that some of us, with DEXA's in the mid -3's, have painful and debilitating fractures. Meds can be really helpful.

Your mother was fortunate and possibly smart about her moving, but bones can get fragile enough to break easily, especially the spine.

I chose Tymlos over Evenity. At first people seemed to tolerate Evenity really well and I was going to follow Tymlos with it but lately posts have been negative. I am sorry you are one of them.

Thanks for your reply! I am grateful for meds but Evenity has been a challenge for me. Am concerned about my spine and appreciate your input. Hope all goes well for you.

I just saw your post. I completed 11 months of Evenity and am not getting the last injections to complete the 12 mos. My arms after injection were always tender for a couple of days which is not a big deal. However, I am active...walk, bike, mountain bike, ski, etc. and have always done so. Have a family history of low bone density but no one has broken a bone so I avoided meds like crazy due to side effects but did decide to try Evenity as my spine density was getting worse. I felt great and strong before Evenity but not now. Side effects for me seemed to get pretty noticeable around month 8 of injections. I now have weakness and stiffness in hips, shoulders, back of hands...I was trying to "tough it out" but I feel like I've ruined my health. I literally am uncomfortable just getting out of bed. I am hoping that these things will get better as Evenity leaves my system. I am 66 and otherwise was 100% healthy. Not happy at the moment and haven't had a scan yet to see if it helped at all. I am soooo hesitant to take anything to follow up after ending Evenity. My mom is 92, active and has had osteoporosis since her 40s and never taken meds and never broken a bone. Kind of wish I hadn't used Evenity as no one seems to be able to tell me if what I am experiencing will dissipate. I am just keeping active and pushing through the discomfort at this point. My last injection was only a month ago but I just couldn't justify having that last injection the way I feel.

Good morning, @lauratys,
I, too, am in a similar situation. I stopped Evenity after the 6th dose because of significant side effects fatigue, tingling in hands, feet and scalp, and fluctuations in blood pressure. Pretreatment my blood pressure was 122/77. It would spike after the injections to 151/101. Since the drug has a heart attack and stroke risk, I had to listen to my body.and discontinue the injections. They put me on Alendronate 70 mg to stabilize my gains, but I experienced daily migraines. I do have a history of migraines, but they would only
occur a couple of times a year. Almost 3 weeks after my second dose of Alendronate, the migraines stopped and I haven't had a headache since. It's been 3 months. I think I am just sensitive to medication. I contacted AMGEN to report my concerns about Evenity. It's a new drug and long term data isnt available yet. I'm no chemist, but Evenity has a half life of approximately 2 weeks. Since you were almost done with the protocol, you probably still have a lot in your system. They usually recommend a bisphosphonate after Evenity to stabilize gains. Please talk to your doctor about next steps and I hope he can give you his experience with patient side effects. Best wishes for a successful journey.

I just saw your post. I completed 11 months of Evenity and am not getting the last injections to complete the 12 mos. My arms after injection were always tender for a couple of days which is not a big deal. However, I am active...walk, bike, mountain bike, ski, etc. and have always done so. Have a family history of low bone density but no one has broken a bone so I avoided meds like crazy due to side effects but did decide to try Evenity as my spine density was getting worse. I felt great and strong before Evenity but not now. Side effects for me seemed to get pretty noticeable around month 8 of injections. I now have weakness and stiffness in hips, shoulders, back of hands...I was trying to "tough it out" but I feel like I've ruined my health. I literally am uncomfortable just getting out of bed. I am hoping that these things will get better as Evenity leaves my system. I am 66 and otherwise was 100% healthy. Not happy at the moment and haven't had a scan yet to see if it helped at all. I am soooo hesitant to take anything to follow up after ending Evenity. My mom is 92, active and has had osteoporosis since her 40s and never taken meds and never broken a bone. Kind of wish I hadn't used Evenity as no one seems to be able to tell me if what I am experiencing will dissipate. I am just keeping active and pushing through the discomfort at this point. My last injection was only a month ago but I just couldn't justify having that last injection the way I feel.

I just saw your post. I completed 11 months of Evenity and am not getting the last injections to complete the 12 mos. My arms after injection were always tender for a couple of days which is not a big deal. However, I am active...walk, bike, mountain bike, ski, etc. and have always done so. Have a family history of low bone density but no one has broken a bone so I avoided meds like crazy due to side effects but did decide to try Evenity as my spine density was getting worse. I felt great and strong before Evenity but not now. Side effects for me seemed to get pretty noticeable around month 8 of injections. I now have weakness and stiffness in hips, shoulders, back of hands...I was trying to "tough it out" but I feel like I've ruined my health. I literally am uncomfortable just getting out of bed. I am hoping that these things will get better as Evenity leaves my system. I am 66 and otherwise was 100% healthy. Not happy at the moment and haven't had a scan yet to see if it helped at all. I am soooo hesitant to take anything to follow up after ending Evenity. My mom is 92, active and has had osteoporosis since her 40s and never taken meds and never broken a bone. Kind of wish I hadn't used Evenity as no one seems to be able to tell me if what I am experiencing will dissipate. I am just keeping active and pushing through the discomfort at this point. My last injection was only a month ago but I just couldn't justify having that last injection the way I feel.