B12 deficiency leading to headaches & face tingling/numbness?

Did you get shots or supplementation between tests? B-12 goes up quickly with shots

Sorry, I should have clarified that, I started the B12 injections after the 2nd blood test.

There is a gene, MTHFR, that affects B12. My family has a few people that need B12 shots regularly and have this gene variation.
Best of luck to you.

Thank you, that is very helpful, I will look into it.

Yes, they have, thank you. 😊

@rwinney, @plo99ca, and all... I was first diagnosed with B12 deficiency years ago, quite severe, after developing numbness in my feet and legs, tingling, and neuropathy in my hands as well. I have multiple issues with nerve pain, legs, weakness, and others. I've taken Super B supplements for many years and then began several years ago giving myself B12 injections every 2 weeks. Now, as the testing shows I'm still low, I give shots weekly. I'm having bloodwork this week to see how this area is doing as well as iron and ferritin levels, and all else.

Interestingly, my son, 55 years old, has acute B12 deficiency and must take a very expensive medication in pill form to keep his levels up. This appears to work well for him. So, apparently, we have the dreaded gene for this deficiency and will deal with it ongoing.

My thoughts include poor absorption by the intestines since I have to have frequent iron infusions due to a low ferritin issue. They help immensely.

I'm so glad to find this discussion. I'm finding these issues are becoming more important as I get older. At 76, I need every bit of supplementation out there! God is good. I have Mayo Clinic nearby, wonderful kindness and care, and new friends these last years from Mayo Connect. What joy you have given me, good information, insights, friendships, and a new understanding of my multiple issues. I'm no longer alone in this journey.

Thank you all for your sharing, your encouragement, your love, and your support....be well, and be blessed. elizabeth

I take a B12 oral supplement ,every day I know that it works ,because I could now dig holes in concrete with my nails .Pre B12 ,my nails crumbled and were quite soft . B12 is needed by most of your body, Using a spray is more acceptable than needles , for me ,

B-12 only come from animal sources. Are you a vegetarian?

I’m not a vegetarian, I eat a very varied diet with plenty of meat.

Good. Eat your meat! Only, some have difficulty absorbing V-B12. I am so glad that you so far don’t have to have the shots. I also have had difficulty with V-b12. I eat plenty of meat also; however some of the medications that I am on make it difficult to absorb. So far just the pill has been sufficient. I hope and pray the best for you.