MTHFR mutation and supplements to take

Posted by contilucy1960 @contilucy1960, Aug 27, 2021

I have been taking up to 11 vitamins and supplements a day as prescribed by a doctor 7 years ago, due to MTHFR gene mutation. I would like to update what supplements and vitamins are needed for this condition. Any input welcome!

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@malida1000

Hello,

I was told by a pharmacist that the Orthomolecular supplements for the MTHFR are the best. Unfortunately, this pharmacy closed and now I have to find the medications elsewhere. I was taking 3 supplements: 1) Methyl CpG; 2) N-Acetyl Cysteine (NAC) but I cannot remember the other one. Would it be Methyl B Complex? Or is it Methyl B12? I would appreciate an answer. Thank you.

Laurie

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You can find supplements at Methyl Life website, plus they are extremely knowledgeable about mthfr.

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@contilucy1960

What I'm taking is B12 liquid, Vitamin D, methyl folate, COQ10, Nutrient 950, Magnesium, Vitamin B6, then I also take iron, fish oil, calcium for bone strength, Vitamin E to prevent tardiv dysconesia. Does anyone know if this is the best thing to do, to take all these supplements? Thanks in advance!

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I would take a b- complex suited for methylation- for MTHFR. Sometimes just a b6 Can throw out ur other b- vitamins-best advice is to have ur bloodwork done by someone who does functional testing or uses spectrum- looking at the cellular level. Then they can precisely tell u what would be best for u! Best to not guess- rule of thumb. But the fact you are supporting your system is good with nutritional support!

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@wwllmsdn

I would take a b- complex suited for methylation- for MTHFR. Sometimes just a b6 Can throw out ur other b- vitamins-best advice is to have ur bloodwork done by someone who does functional testing or uses spectrum- looking at the cellular level. Then they can precisely tell u what would be best for u! Best to not guess- rule of thumb. But the fact you are supporting your system is good with nutritional support!

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Hi @wwllmsdn, do you also have MTHFR mutation? What has this meant for you?

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@cormar

I have tested positive for being double heterozygous for the MTHFR gene mutation. I can't find much info on this particular mutation combination, but I have been taking 3,000mcg of l-methylfolate and wonder if I should be taking more. I suffer from depression and anxiety, fibromyalgia and various muscle aches and pains.

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Hi @cormer,

I have the same conditions…diagnosed 22 years ago. I have spent a lifetime trying to find real healing from all of this and just recently found out about the gene mutations.
I would love to hear more about your journey and what helps.

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@lizthepa06

Hi @cormer,

I have the same conditions…diagnosed 22 years ago. I have spent a lifetime trying to find real healing from all of this and just recently found out about the gene mutations.
I would love to hear more about your journey and what helps.

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@lizthepa06, welcome. There’s been concern that certain health issues may be associated with MTHFR mutations, so testing has become more mainstream over the years. MTHFR status may or may not be affect health. More research is needed to determine the true impact, if any.

Have you had genetic testing to confirm that you have a MTHFR genetic mutation? You may wish to ask your doctor about the benefits and risks of testing.

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I found this discussion searching for answers re: old genetic testing (prior to it officially being considered a “real” concern) revealing that I have two polymorphisms, both C677T and at least one copy of A1298C. If Mayo Clinic recognizes this as affecting health and requiring special nutritional/supplemental intervention, then where must I look for their stance on this condition? How do I schedule an appointment if I can’t find the proper department? I have a huge cluster of health issues and have had since youth including MTHFR related cancer and need current and official genetic testing for insurance and need proper nutritional guidance. My small-town clinic has not been helpful.

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@inminn

I found this discussion searching for answers re: old genetic testing (prior to it officially being considered a “real” concern) revealing that I have two polymorphisms, both C677T and at least one copy of A1298C. If Mayo Clinic recognizes this as affecting health and requiring special nutritional/supplemental intervention, then where must I look for their stance on this condition? How do I schedule an appointment if I can’t find the proper department? I have a huge cluster of health issues and have had since youth including MTHFR related cancer and need current and official genetic testing for insurance and need proper nutritional guidance. My small-town clinic has not been helpful.

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@inminn, you're asking good questions. I recommend calling Mayo Clinic and talking to a scheduler about where to start, possibly Clinical Genomics. http://mayocl.in/1mtmR63

Clinical Genomics https://www.mayoclinic.org/departments-centers/clinical-genomics/overview

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I did try to secure an appointment with endocrinology, because I had been seen there before so was advised to try there first but my request was rejected. I’ll try Genomics, thank you.

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I have also been diagnosed with a double mutation of MTHFR and I take one EBN5 in the morning and at night. Has anyone else been prescribed this for the double mutation?

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