Anyone know about daridorexant (Quviviq) for insomnia?

Insomnia can result from anxiety and/or depression, or it can be the root cause of this type of mood change.
Sounds like maybe your insomnia grew out of anxiety/depression? If so, getting some relief from those may give you some relief from insomnia. In my case, the mood changes are the direct result of serious ongoing insomnia. On days after I get adequate sleep, my mood is often quite good, it's like I'm exhilerated to feel normal. On days after inadequate sleep, I obviously have fatigue but also symptoms that are flu like. It is really limiting in terms of making/following trough with plans, any kind of travel, it's really tough on relationships. And I think these limitations, together with missing important events like Christmas, create extreme distress and very low mood that will last for days, sometimes even after sleep returns, because I'm so generally sleep deprived, and I am feeling the effects of missing yet another important event with those I care about. Vicious cycle. I've done CBT-I as well, and feel the same as you, valuable tools for coping and not obsessing with sleep, but no lasting significant improvement in the insomnia itself, except, I used to go entire nights with no sleep; I do sleep now, just not long enough or deep enough, and I wake up 4,000,000 each night. Slight exxageration?
Best ~ keep working on that anxiety!! Metitation = bravo

Believe it or not I am old enough to have been using the cognitive strategy way before it was called CBT (Rational Emotive Therapy created by Albert Ellis in the 50's). It worked for well for me in the 80's (not 50's), but I wasn't consistent. It would not be helpful for me now, I believe, because my Narcolepsy is in full control of my emotions. I'm an over-sleeper, and don't hve insomnia. Otherwise I stongly recommend it for logical thinkers.

@netter9064, I moved your query about daridorexant (Quviviq) for insomnia to this existing discussion:

- Anyone know about daridorexant (Quviviq) for insomnia? https://connect.mayoclinic.org/discussion/new-insomniasleep-medication/

I did this to bring everyone talking about this medication and insomnia into one discussion like @chuckiepoo1 @cmd @sleepy40 @ripley @lauralouisenelson @rocketjs @timbrownfl

Have you tried shiatzu massage or acupunture for insomnia and anxiety? Its The Only thing It really helped me With my insomnia plus anxiety i SWEAR. I highly recomended that to u'all . I was suffering sever insomnia and tried all type of pills.. and The few workin' (strong hypnotic) left me like a zombie The Next day literally plus my anxiety increased and increased, in adittion that didnt even work all days. . i decided give shiatzu massage and acupunture a try . And its worth tryin one hundred per cent . It changed my Life , i just Hope these words be helpful to anyone. ( I was kind of refusing tryin INITIALLY, but thanks god i did. Just go ) xxoo

The scientific study results on this drug look pretty good. The clinical studies were performed by the manufacturer.

As far as the direct effect on insomnia :
"Phase Ⅲ data that demonstrated better sleep onset, maintenance, and self-reported total sleep duration." Nice!

As far as the daytime symptoms from insomnia the studies concluded:
"During the day, patients reported feeling less emotionally and physically weary, less drowsy, and livelier." Also nice!

The downside - watch for these:
"Common adverse effects reported in the studies included headaches, somnolence or fatigue, hypersomnia, lethargy, dizziness, vertigo, labyrinthitis, nausea, vomiting, and procedural nausea."

Based on these studies the drug was approved quickly without controversy early last year by both Europe and the US. More studies are underway in Japan.

For me, the science is way more important than individual anecdotes because of controls, statistical analysis, and the numbers of people involved. I would conclude that this drug is definitely worth a try.

(FYI, I have a PhD in Philosophy and my dissertation was in the field of scientific knowledge).

-Tim

I tried it for the first time last night. I cant recommend it.
It did not make me sleepy. It did for some reason make a song play over and over in my head. I thought maybe I took too low of a dose and after 3 hours awake I took one more. I finaly fell asleep after another hour. But it was fitful spasmatic sleep. I had a few panic filled dreams. And still the constant replaying of the same song. Has anyone else had a similar experience? I cant imagine this drug making it through trails based on my experience. I may try it again but it will not be on a work day.

I did not like the drugs you mentioned and they’re not meant to be long term. I just finished a long taper from Ativan and have been in mirtazapine (Remeron) since January. Has really helped my sleep.
Tried Trazadone but affected my liver enzymes. Others I know have found success with this. Good luck!!

I tried it and didn’t like it. I felt sleepy but couldn’t get to sleep very well. It gave me a hangover the next day…gave it four try’s….

For me it's 2 Benydryl 5mg Melatonin and the theme song from Gilligan's Island going through my head.

I am takin Quviviq and it works! My insurance covers it (Blue Cross/Blue Shield). I am very satisfied.