Jak2 and Vitamin D3

Hi Steve,
Welcome to this wonderful site. I have ET JAK2 and have found the site so helpful.

Since you are in the research stage I suggest you also look at healthunlocked.com. There has been a lot of discussion also on PV and Pegasys. It is a site based in the United Kingdom by MPN Voices but participants are from around the world.
Best wishes, Eileen

Hello @lindaw123

I appreciate this thoughtful question. I did some research online and found the results of a research study on this topic at the National Insitute of Health website. Here is the link,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053540/. The article is titled: Vitamin D Deficiency and Janus kinase 2 V617F Mutation Status in Essential Thrombocythemia and Polycythemia Vera."

If you read the study and especially the Conclusion it says:

"Conclusion
There was a remarkably higher prevalence of vitamin D deficiency in JAK2 mutation-positive ET and PV patients. These patients should be carefully evaluated for vitamin D deficiency. More studies are required to further investigate the association between JAK2 and vitamin D.

Keywords: vitamin D deficiency, chronic myeloproliferative neoplasia, polycythemia vera, essential thrombocythemia"

How are you feeling with your diagnosis?

I am on Hydroxyuria for ET. I have the JAK 2 mutation as well. After reading this article I intend to start taking Vitamin D supplement. Any suggestions on the dosage?

Hi @sandy1959

On Mayo Connect, we are not medical professionals, just patients like yourself. For information on whether or not Vitamin D supplements are appropriate for you and for information on recommended dosages, please consult with your physician.

Checking your current Vitamin D level is done by a simple blood test. Has your Vitamin D level been tested recently?

Thank you for your response. My Vitamin D levels have not been checked. My MCH levels and platelet levels were flagged high. I am on 500mg of Hydroxyuria and a low dose aspirin. My B12 and iron levels have been high in the past. I will certainly ask the doctor about the Vitamin D. Best Regards

Hi @sandy1959,

That all sounds good. I would enjoy hearing from you again. Will you post after your Vitamin D levels have been checked?

Hi Steve,
Welcome to this wonderful site. I have ET JAK2 and have found the site so helpful.

Since you are in the research stage I suggest you also look at healthunlocked.com. There has been a lot of discussion also on PV and Pegasys. It is a site based in the United Kingdom by MPN Voices but participants are from around the world.
Best wishes, Eileen

I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested positive for Jak 2 and a bone marrow biopsy confirmed it. I am on 2 baby aspirin a day and phlebotomy’s as needed. I’m wondering if anyone has found relief for the itching and minor fatigue. Unless chemo would slow this disease, I’ll stay with my current regiment. Any advice?

Have you researched black seed oil?

I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested positive for Jak 2 and a bone marrow biopsy confirmed it. I am on 2 baby aspirin a day and phlebotomy’s as needed. I’m wondering if anyone has found relief for the itching and minor fatigue. Unless chemo would slow this disease, I’ll stay with my current regiment. Any advice?