Low levels of IgG IgA IgM

Hello just curious if anyone has a similar medical profile. My igg's are dropping. Dx with sjogrens, SFN, dysautonomia, and now crohns. Immunologist says not a true CVID because of my lack of UR infections. Sure have gut stuff tho. Have low igg and igm and now my iga is also below the cut-off. Ty

Hello @lilymol. I found a discussion with members who have discussed this very topic so you will notice that I have moved your post here: https://connect.mayoclinic.org/discussion/low-levels-of-igg-iga-igm/

I did this so you can review what has been shared in the discussion already if you'd like and also so you may connect with members such as @jean9v.

What is your Immunologist suggesting for next steps?

Have you had fecal analysis- Sungenomics advertises Flore for a by mail in collection. Your situation reminds me of the difficile infection. This company supplies probiotics tailored to individal biomes. I am in process of signing up.

I got lymphoma mantel cell. Went thru Rituximad and Bendamustine. For 6months. Five year in remission on clinical trail 100mg of Acalabrutinib 2 time a day. My immune has been low resulting in sinus infection bronchitis. And Covid 3 times since Oct 2022
My oncologist think that the chemo drug killed my IGG he order the IGG infusion. I can not find any data that rituximab lowers the immunity. Any advice. On this

@ctack545 You asked about rituximab lowering your immunity. It may not, but you also get bendamustin which does affect the immune system. I found the following statement in my Drug book:
“Bendamustine affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.
Common side effects of bendamustine may include:
fever, cough, mouth sores, trouble breathing;
low blood cell counts;
nausea, vomiting, diarrhea, constipation;
headache, tiredness;
rash; or
loss of appetite, weight loss.’
Most chemotherapy drugs will affect your immune system. If you are very concerned, you can have a discussion with your doctor.
Have you had any other infection that worry you?

Five years later???

@ctack545 I also found this discussion that might have some good information for you:
https://connect.mayoclinic.org/discussion/low-levels-of-igg-iga-igm/
Will you let me know if these articles are helpful?

@ctack545 I’m sorry, I didn’t realize that there was 5 yr, interval. What does your oncologist say about this?

He think my IGG is low because of the rutixion I took April 2018 cause my numbers to be low.

Well the treatment worked for my NHL Mantal cell B Lymphoma Reduced All sites to remission. First time treatment or the alcalabrinab