ANA Positive - Mitotic Spindle Fibers and Nuclear Speckled

@glasslynne You’ve asked a difficult question that we’re unable to answer as we’re not medically trained.
This Mayo Clinic article may have some information for you:
https://www.mayoclinic.org/tests-procedures/ana-test/about/pac-20385204
What has your doctor said about the numbers?

She is a new doctor and she is the one who did the 2022 test. She said the result is suggestive of an autoimmune disorder and referred me to a rheumatologist. I have an appointment with one, but it's not for a few months. I do have symptoms of something going on, and my mother had Sjogren's so that is a concern. I'm mostly just hoping someone who has also had a mitotic result and received a diagnosis might notice my post and share their diagnosis.

Lynne, there are several discussions in the Autoimmune Diseases group about positive ANA testing. Here's a short list.

– Positive ANA’s and GI issues: https://connect.mayoclinic.org/discussion/positive-anas/
– Help! Positive ANA with swelling, joint and muscle pain and brain fog: https://connect.mayoclinic.org/discussion/help-2/
– Terrible fatigue for months, positive ANA: https://connect.mayoclinic.org/discussion/terrible-fatigue-for-months-positive-ana/
– Question on ANA and dsDNA: https://connect.mayoclinic.org/discussion/question-on-ana-and-dsdna/
– Positive ANA and ENA Panel: https://connect.mayoclinic.org/discussion/positive-ana-and-ena-panel/

What led to your getting regular ANA testing since 2014? Do you have unexplained symptoms that concern you?

Yes, I do and they concern my doctors as well. I'm really only interested in the mitotic patterns. They're rare and so even in the literature there are few examples and they aren't usual for diagnosing conditions. I just wanted to talk to anyone that has them to gather more data for myself.

I found this on the Internet. https://pubmed.ncbi.nlm.nih.gov/26987702/

I have the same and also my C-reactive protein was high so along with my symptoms and testing I was diagnosed with Psoriatic Arthritis.

I recently had a positive ana with 1:320 titer ac-25,26 mitotic spindle fibers, NuMa-like pattern.

Did you get a diagnosis?

I have the mitotic pattern ac25 and I have a lot of sickness in the family. My mother had Myotonic Dystrophy but there is an underlying disease that I have desperately been trying to figure out. So far my sister has Psoriatic Arthritis and Joint Hypermobility syndrome so maybe those can be a clue. what is weird is my pattern changed so this signifies that maybe during my first test i was in a flare of some kind. My pattern went from nucleolar to this mitotic spindle fiber speckled pattern

my sister has that! this is a big clue in my hunt for answers!! thanks for posting