B-6 vitamin danger!

Greetings @timcryan, and welcome to Connect. This is a group of patients and caregivers who help others with quality of life issues. I would absolutely call nighttime Neuropathy pain something that can impact your quality of life. It can also make you sleep-deprived. So let's have a look. First of all, how long have you had neuropathy? Have you been diagnosed? And has that diagnosis included a skin test biopsy?

I have had SFN small fiber neuropathy for a number of years. Mine is related to trauma accidents and surgeries over the last 50 years. Ever since trying medical cannabis for the pain and tingling and numbness of SFN, I have been able to sleep pretty well. I use a dropper of a CBD/THC tincture that I take before bedtime. Mine happens to be a 2:1 mixture of CBD and THC. Within about 20 minutes I wander off to sleep and wake up refreshed in the morning.

What have you tried? I am not good with opioids or OTC medications. My PCP is very supportive and together we evaluate and plan my daily routine. Because I succumb to anxiety quite easily I also use Duloxetine in the morning to take the edge off the anxiety that can create pain.

In addition to tinctures, I use a CBD:THC topical for both acute and chronic pain.

I am going to have to have some more information from you so that I can refine these suggestions to make them provide the greatest support.

Where on your body is the neuropathy pain the worst?
May you be free of suffering and the causes of suffering.
Chris

I also had multiple surgeries, lumbar fusion, cervical fusion and both hip replaced.
all within the past 16 years. I can deal with the pain n my feet and lower legs ok during the day but at night my feet feel like the are on fire. my Neurologist put me on Gabapentine and I take 600 mg. at bedtime. I take 600 mg at bedtime to help me sleep. I go to bed with cold and blue feet/toes due to Rauynauds and 1 hr. later my feet are on fire. I use Aspercream with Lidocaine. It helps a little. This has been going on for a long time and I am wondering of it is due to the Gabapentine. Has anyone had the same experiencke? I also have a other rare condition called Erythromelalgia which I developed after my first back surgery in Jan. 2005. Went to Mayo's twice and they confirmed iot. Know what iot is but don't have a cure. Does anyone else has/had worsening symptons due to Gabapentine?

I also had multiple surgeries, lumbar fusion, cervical fusion and both hip replaced.
all within the past 16 years. I can deal with the pain n my feet and lower legs ok during the day but at night my feet feel like the are on fire. my Neurologist put me on Gabapentine and I take 600 mg. at bedtime. I take 600 mg at bedtime to help me sleep. I go to bed with cold and blue feet/toes due to Rauynauds and 1 hr. later my feet are on fire. I use Aspercream with Lidocaine. It helps a little. This has been going on for a long time and I am wondering of it is due to the Gabapentine. Has anyone had the same experiencke? I also have a other rare condition called Erythromelalgia which I developed after my first back surgery in Jan. 2005. Went to Mayo's twice and they confirmed iot. Know what iot is but don't have a cure. Does anyone else has/had worsening symptons due to Gabapentine?

Greetings @timcryan, and welcome to Connect. This is a group of patients and caregivers who help others with quality of life issues. I would absolutely call nighttime Neuropathy pain something that can impact your quality of life. It can also make you sleep-deprived. So let's have a look. First of all, how long have you had neuropathy? Have you been diagnosed? And has that diagnosis included a skin test biopsy?

I have had SFN small fiber neuropathy for a number of years. Mine is related to trauma accidents and surgeries over the last 50 years. Ever since trying medical cannabis for the pain and tingling and numbness of SFN, I have been able to sleep pretty well. I use a dropper of a CBD/THC tincture that I take before bedtime. Mine happens to be a 2:1 mixture of CBD and THC. Within about 20 minutes I wander off to sleep and wake up refreshed in the morning.

What have you tried? I am not good with opioids or OTC medications. My PCP is very supportive and together we evaluate and plan my daily routine. Because I succumb to anxiety quite easily I also use Duloxetine in the morning to take the edge off the anxiety that can create pain.

In addition to tinctures, I use a CBD:THC topical for both acute and chronic pain.

I am going to have to have some more information from you so that I can refine these suggestions to make them provide the greatest support.

Where on your body is the neuropathy pain the worst?
May you be free of suffering and the causes of suffering.
Chris

Welcome @timcryan, I'm sorry to hear you are having more neuropathy pain at night. I'm wondering if you might find this discussion helpful -- Neuropathy Pain at Night: What helps?: https://connect.mayoclinic.org/discussion/night-pain-2/

Is the pain mostly in your feet and legs?

Hi @neasrenrut, I would like to add my welcome to Connect along with @amandaburnett and other members. Your post was moved to this neuropathy discussion that has posts about calcium, B-6, neuropathy issues - B-6 vitamin danger!: https://connect.mayoclinic.org/discussion/b-6-vitamin-danger/

There is also another discussion that might be helpful
-- Calcium Scan: https://connect.mayoclinic.org/discussion/calcium-scan/

You mentioned your CT scan was 653. Here are a couple of references that maybe helpful with information related to your CT scan results:

--- "Over 400 Extensive evidence of CAD" Cardiac CT for Calcium Scoring: https://www.radiologyinfo.org/en/info/ct_calscoring
--- "The multivariate analysis revealed that the presence of CAD was a statistically significant risk factor for ischemic peripheral neuropathy." -- Prevalence and Risk Factors for the Peripheral Neuropathy in Patients with Peripheral Arterial Occlusive Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480317/

I'm not a doctor and have no medical training but I'm not sure anyone can answer your first question will the painful neuropathy decrease with lower cholesterol numbers but my guess is that it would take more than lowering the cholesterol numbers. Your second question is really a good and one you should discuss with your doctor. My doctor has wanted me on statins for a long time but I'm not about to start them because I have neuropathy and do not want to make it worse. I might think differently if I had a condition that would put me in a higher risk. Then I would have to weigh my options and discuss with my doctor. There are things you can do to lower cholesterol naturally but you really have to work at it. Mayo Clinic has a good place to start - https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/reduce-cholesterol/art-20045935

Are you on any treatments for your Hypercalcemia?

hello and thank you for answering me . my dr is in in KS and will not prescribe cbd/thc. i tried Duloxetine and it made me deathly ill. Also I have take Gabepentine which only help to get me to sleep but the burning wakes me up'
the neurophathy has been going on for several years now. I have been diagonised but no skin test. The pain/numbness is on the feet and lower legs.
you say you have more info, please state what this is

Hi all, I’m new to the group and hope to find some answers. I was diagnosed in January with high levels of vitamin B6, per the lab sheet normal is 5.3 – 46.7 ug/L and I was at 93. I had been having burning sensations/pain on my hands, feet, face and sporadically on other areas for quite a while. I visited several doctors and finally ended up at an allergist office (he’s the first one to think to test for B6). He felt the B6 was causing peripheral neuropathy. His advice was to stop taking all vitamin supplements and protein shakes and retest in 3 weeks. I spent the last month drinking 90 oz of water per day and really trying to limit my B6 intake. Fast-forward to last week and the blood work came back with normal B6 levels, 22 ug/L. I guess the questions at this point are; how long does it take for the symptoms to resolve and what follow up should I be doing?

For those who have taken b6 supplements:
Check out this website.
http://Www.understandingb6toxicity.com
There is a connection with small fiber neuropathy.