How did you manage the pain side effects of Prolia?

Does Mayo Clinic in Jacksonville have an ethos radiation machine? My brother in law has stage 4 bone cancer and is searching for one.

I have been on Generic Fosamax for two years, no issues at all. You take it once a week,
so it would not be hard to get off of its if issues developed. I talked with two Orthopedic
doctors before I was willing to try this med. I will be getting a bone scan when the
Corona virus lets up. Even with gloves on, I use a knuckle to push an elevator button.

Good Morning! I know each person must make their own choice about medications to use based on their own individual needs. But I feel I must tell you that I used Prolia for Osteoporosis for 3 yrs & now I am dealing with 'death of the jaw bone' or medication related osteonecrosis of the jaw. This jaw bone issue occurred after a dental procedure. I was told that using Prolia for only 3 yrs was not a long enough time period to produce the Prolia jaw problem, & that the dental procedure would be safe. I had previous dental implants prior to using Prolia without any issues, and trusted in the diagnosis given to me. But now, I am dealing with a hole in my jaw which is exposing bone. I am taking daily antibiotics & pain killers. I live with incredible pain & loss of quality of life. It has been 30 days since the dental procedure & the pain is still incredible. I do not know if my jaw will ever heal. I am no longer taking Prolia, & my Ortho Doctor wants me to start on Tymlos. I need to ask my Ortho Doctor if Tymlos will assist in rebuilding my damaged jaw bone? For now I am praying the hole in jaw will eventually heal, so that I can try to get back to living without incredible pain every day.

I'm so sorry you are having such terrible jaw pain. I experienced a similar problem after only one prolia shot. Two months after receiving the prolia treatment, I began having pain in my jaw where I had three implants that had been in place for twenty years. I had oral surgery to remove the implants, but the jaw failed to heal and the bone was exposed, causing terrific pain. I took antibiotics and round the clock pain killers for three months, when suddenly the bone that was exposed loosened and was removed by my dentist. After that, the pain resolved, but the healing is not complete five months after the surgery. I hope you find relief soon.

Thank you for sharing your experience. I am happy to hear that your pain is finally resolved, but so very sorry that after five months the healing is still not complete. I hope that your jaw will be fully healed soon. Take care!

@pine4234: I've been on Prolia for about 5 years now. I had and (based on the pain that I still have) currently have bilateral sacral insufficiency fractures and bilateral pubic insufficiency fractures; I roll over and my bones crunch. However, my bone density tests come back normal. My Rheumatologist said that the fact that I have the insufficiency fractures indicates I have osteoporosis. The only side effect I have, which is becoming increasingly problematic, is severe mouth ulcers. I find myself dreading my next shot in about a week because the ulcers are so painful and will stay around until about 3 weeks before the next shot. I can't eat fruit, fresh or canned or frozen, or anything even remotely acidic or spicy so long as I have the ulcers. Mr doctor increased my folic acid so that I now take Leucovorin, but it still doesn't help much.

Pine, I hope you don't develop this or any other side effect. But for the rest of the forum, does anyone else have this problem? If so, do you have any helpful remedies? Thanks!