1. < MAC & Bronchiectasis

0.9% Saline?

Posted by beatrixflower @beatrixflower, May 9, 2021

Hi,
Since I am pestering folks, I would like to ask about this saline dose:

Sodium chloride 0.9 % Nebulized
Inhale 3 mL into mouth/lungs daily

Is 0.9% a beneficial amount? I feel like I see 3% and 7% used by my most. Does this really mean 0.9% or am I reading it wrong? Would that even be helpful or why would it be prescribed at such a low dose?
Thank you!

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Mentor
Sue, Volunteer Mentor | @sueinmn | May 10, 2021

.9% saline is the normal one used for most nebulizing. However, there have been some studies that show MAC bacteria cannot survive in 7% saline, so many of us with a history of MAC infections nebulize with the higher dosage in hopes of keeping bacteria colonies in our lungs under control. Dome cannot tolerate the 7%, so use 3% as a "happy medium".
Here is a link to a highly technical article for you to wade through: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850692/pdf/13104_2016_Article_2054.pdf
Of most interest is the table on page 4.

I did notice on another discussion that you recently had the experience of coughing up blood, so you should definitely consult your dosc before trying the higher concentration, because it does tend to irritate the lungs.
Sue

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1 reply
ginak | @ginak | May 10, 2021

@beatrixflower I started with .09%, I think that’s pretty much the %of sodium in our tears and what the Dr will first prescribe. I then went to 3% and eventually to 7%. The 7% can be very irritating at first, so I would suggest a gradual change if you decide. The .09 will help loosen some of the mucus in your lungs to help with clearance but I don’t think it makes the lungs “inhospitable” to any NTM.

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2 replies
beatrixflower | @beatrixflower | May 10, 2021
In reply to @sueinmn ".9% saline is the normal one used for most nebulizing. However, there have been some studies..." + (show)
@sueinmn

.9% saline is the normal one used for most nebulizing. However, there have been some studies that show MAC bacteria cannot survive in 7% saline, so many of us with a history of MAC infections nebulize with the higher dosage in hopes of keeping bacteria colonies in our lungs under control. Dome cannot tolerate the 7%, so use 3% as a "happy medium".
Here is a link to a highly technical article for you to wade through: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850692/pdf/13104_2016_Article_2054.pdf
Of most interest is the table on page 4.

I did notice on another discussion that you recently had the experience of coughing up blood, so you should definitely consult your dosc before trying the higher concentration, because it does tend to irritate the lungs.
Sue

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Hi Sue,
Thank you for the explanation. That makes sense. I have a new doctor that was willing to prescribe this so since I have coughed up blood maybe I should give it a try. I will read the article you sent today.
Thank you again!
Warmly,
Darla

REPLY
beatrixflower | @beatrixflower | May 10, 2021
In reply to @ginak "@beatrixflower I started with .09%, I think that’s pretty much the %of sodium in our tears..." + (show)
@ginak

@beatrixflower I started with .09%, I think that’s pretty much the %of sodium in our tears and what the Dr will first prescribe. I then went to 3% and eventually to 7%. The 7% can be very irritating at first, so I would suggest a gradual change if you decide. The .09 will help loosen some of the mucus in your lungs to help with clearance but I don’t think it makes the lungs “inhospitable” to any NTM.

Jump to this post

Hi Gina,
Thank you for your response. That is helpful to know that it will still have loosen some of the mucus. It sounds like I should get started on it so I can work my way up to the 7%. Thank you!
Warmly,
Darla

REPLY
thumperguy | @thumperguy | May 11, 2021
In reply to @ginak "@beatrixflower I started with .09%, I think that’s pretty much the %of sodium in our tears..." + (show)
@ginak

@beatrixflower I started with .09%, I think that’s pretty much the %of sodium in our tears and what the Dr will first prescribe. I then went to 3% and eventually to 7%. The 7% can be very irritating at first, so I would suggest a gradual change if you decide. The .09 will help loosen some of the mucus in your lungs to help with clearance but I don’t think it makes the lungs “inhospitable” to any NTM.

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ginak, this post sums up the concentration matter very nicely. Don

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1 reply
ginak | @ginak | May 12, 2021
In reply to @thumperguy "ginak, this post sums up the concentration matter very nicely. Don" + (show)
@thumperguy

ginak, this post sums up the concentration matter very nicely. Don

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Thanks

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