JAK2 Mutation, Low Iron and High Platelet count

I would like info on EPO value and how that relates to ET and JAk 2. Can EPO value fluctuate? What are the markers for an EPO test? What treatment is recommended? What do I look at in a CBC test. ?

Actually my Dr just ordered the EPO bloodwork for me. I have MDS/MPN-RS-T with jak2 mutation. My result was 19. I don't go back to dr for a week so unsure of an explanation. I looked it up and believe it has something to do with anemia, and helps to produce red blood cells and identifies problems. Best wishes.

@damari, you may find some answers to your questions regarding erythropoietin levels and essential thrombocythemia in this paper:
- Serum erythropoietin levels in essential thrombocythemia: phenotypic and prognostic correlates https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242882/

And this from Mayo Clinic Labs:
- Test ID: EPO Erythropoietin, Serum: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/80173

Values differ from person to person. Have you talked with a hematologist about the values in your CBC results?

I was recently treated with iron supplements for low iron count. Can this affect the EPO number. My number was 2.

Damari, another good question for your oncologist or hematologist. They can tell you whether you need to stop iron supplements before taking a blood test for a proper reading.

I began taking hydroxyurea ( 2 x 500 mg) on Friday and am in day 4. Moderna SARS 2 vaccine boosted my platelet count to 1.369 million. Blood tests will be taken monthly to track the effect on JAK2 genes production of platelets. My oncologist wants to see me in 3 months. Do others in the group has experience with hydroxyurea and the appropriate number of pills that least interfere with the immune system?

I was diagnosed with ET and Jak 2 I was taking a baby aspirin daily though platelets are in 600's Then I had a low iron count and was told to take iron supplements.. That worked but soon my hematocrit went past the normal scale. Dr. tested for EPO That value came back low. Now he reclassified me with PV though other values are still in ET range. QUESTION: Can iron supplementation affect an EPO value? Can a low EPO revert or is it permanent indicating a new situation? Doctor is suggesting phlebotomy. How serious is PV . Quite worried!

@damari, were you not able to get an answer from your doctor regarding iron supplementation and its possible affect on EPO value? I know you are quite worried and think you need to keep asking your doctors questions until you feel confident in the care and understand your condition of PV or ET better.

In the meantime, I wonder if @mjpm2406 @stevehurlburt @pattitoo @helen2209 @levieta @trillium might have more info for you.

Damari, when do you see your doctor again?

@dwlowrance, I wonder if you would get answers to your questions about hydroxyurea more readily in this related discussion:
- Side Effects Of Hydrea or Hydroxyurea for ET https://connect.mayoclinic.org/discussion/side-effects-of-hydroxyurea-et/

Thank you for your response. So far, I have not gotten an answer. He will repeat the test in 4 weeks and look at all the rbc values. I still hope someone can answer my question of the iron supplementation before that. New Question: My doctor did a test BNP I was diagnosed in March of 2020 with afib. I am on metoprolol and eliquis. My score one year ago was 58 and now it is 133. He said this is NOT a worry. Can these values fluctuate? Since the afib episodes have happened approximately 2 times a month, he thought this is the reason. His suggestion is to let the cardiologist know. What info can you share?