What causes cerebral amyloid angiopathy?

@michaeleta I hope it can be caused by some violent force. It would make me sad to think there was nothing but my Gelsolin and encephalopathy to cause this stuff.

Hello @michaeleta I am not any kind of medical practitioner, but in all the reading I have done the cause of cerebral amyloid angiopathy is not known at this time. I can say I have never read any journal articles saying the cause is blunt force of any kind. Rather it seems the culprit may be the depositing of abnormal amyloid protein.

Hello @michaeleta and welcome to Mayo Clinic Connect. Based on your post, I wanted to share a previous conversation that you might find helpful on this topic.

-Cerebral Amyloid Angiopathy:
https://connect.mayoclinic.org/discussion/cerebral-amyloid-angiopathy/
You will notice that I consolidated your two posts into just this one in this group.

Can you share a little more about your history and if this is a diagnosis or if you are trying to identify based on symptoms?

@IndianaScott, I have a form of cerebral angiopathy sometimes called "disappearing White Matter". It is diagnosed as a portion of my Gelsolin, or AKA Finnish Amyloidosis. It is a rare one, something around 1 of every 2,000,000 physician visits results in the dX. Every person I can find who is diagnosed with FKTN (Fukutin Limb Girdle Muscular Dystrophy- LGGMD-4) who has been tested for Amyloid also also has Gelsolin. Including me, and about 100 others around the world. So the CA might occasionally be a bit mis-diagnosed as only from Gelsolin (GSN - OMIM: 105120 or 137350)

thanks for your reply, but not the area i am looking for.

no. I had a brain injury from an explosion in the military and it was diagnosed later as Amyloid Angiopathy. Trying to figure out why this diagnosis? any ideas what the reason might be?

@michaeleta, not a clue for that reason, unless you had an AA gene from birth, and the injury just activated it. Other than than that, do you have an Amyloidosis gene in your genome? It would seem worth it to find out.

can a TBI be mistaken for CAA from a CT scan from a 70 year old patient who had the injury 30 years previous?

My 71 yr. old daughter has just been diagnosed with Cerebral amyloid angiopathy. Not good news and just searching for some hope!! She has been very sleepy, etc. Can you tell me anything?

My father, 69 years old just got diagnosed with cerebral amyloid angiopathy, after having some memory issues. Such sad news and frustrating that they have no advancement in any treatments for this yet.