Have you tried the new Protocol 525 product for neuropathy relief?

Posted by John, Volunteer Mentor @johnbishop, Apr 21, 2020

I have used the original version of the Protocol 525 product (https://theprotocolworks.com/) since 2016. I have idiopathic small fiber peripheral neuropathy with the only symptom being numbness in both legs. When I started taking the protocol, the numbness was just below my knees. After 2 months, the numbness seems to be just above the ankles which is subjective on my part with no additional testing. I do feel it is a win-win for me as my neuropathy has not progressed like I was told it would by the neurologist. I have continued taking the protocol in hopes that it may continue to roll back the numbness symptoms. I have noticed some new feeling in my feet in the last 2 months. Some feeling has returned to me feet and they seem to feel better lately although I still have the numbness – hard to describe the difference.

The Protocol 525 is not a cure for neuropathy. It treats the pain and discomfort symptoms of neuropathy without the drugs which have their own side effects. Have you tried the Protocol 525 or the original protocol? Did it help? If yes, how? If no, please share.

Note: I have no commercial investment in the protocol and I am sharing this information as someone who has found some degree of relief using this combination of supplements. I also discussed these supplements with my Mayo primary care team before I started taking them. The care team sent them to the pharmacist for review who did not have any major concerns for me taking them.

*** Edited Oct 3, 2023 ***
For more information and a list of the ingredients, please see the frequently asked questions on the Protocol's website here - https://theprotocolworks.com/faq/.

Interested in more discussions like this? Go to the Neuropathy Support Group.

Thanks for that. I noticed acetyl-l-carnitine. I use to take that for mood and for an overall cognitive boost. I may try it again. 😊

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@chuckfrasher

Thanks for that. I noticed acetyl-l-carnitine. I use to take that for mood and for an overall cognitive boost. I may try it again. 😊

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@chuckfrasher
Just want to add, since you mention it, acetyl l carnitine is one of the supplements I have noticed the most benefit from of anything I have taken. Before I started on it (almost 2 years ago) I noticed my energy was flagging when I hiked, especially up hills. ALC was one of the things I found out about in reading about how to help one's mitochondria. After starting on it, that energy drop quickly disappeared and I found myself back to going right up the hills like when I was in my fifties, with plenty of energy. I always take it in the morning, preceded by 300mg of r lipoic acid. I highly recommend it for anyone looking for a boost in their energy. It mad a dramatic difference for me. Best, Hank

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@jesfactsmon

@chuckfrasher
Just want to add, since you mention it, acetyl l carnitine is one of the supplements I have noticed the most benefit from of anything I have taken. Before I started on it (almost 2 years ago) I noticed my energy was flagging when I hiked, especially up hills. ALC was one of the things I found out about in reading about how to help one's mitochondria. After starting on it, that energy drop quickly disappeared and I found myself back to going right up the hills like when I was in my fifties, with plenty of energy. I always take it in the morning, preceded by 300mg of r lipoic acid. I highly recommend it for anyone looking for a boost in their energy. It mad a dramatic difference for me. Best, Hank

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I got a big boost in energy too. I haven’t taken it for a while but I may try it again. Thanks for your input. Chuck

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John
I have had trouble with taking folate before, edginess, neck and back of head pressure. Can you post a way to contact the manufacturer of the 525, so that I can ask about this? Thanks! Sita

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@sita

John
I have had trouble with taking folate before, edginess, neck and back of head pressure. Can you post a way to contact the manufacturer of the 525, so that I can ask about this? Thanks! Sita

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@sita - If you join the group's Facebook page you can search all of the posts to see if someone already has answered your question. I've been taking the protocol since 2016 with no side effect issues. Is your question related to the MTHFR gene? There are members in the group with this gene. Here's a link I found that may help.

- Methylfolate Side Effects: http://mthfr.net/methylfolate-side-effects/2012/03/01/
- MTHFR gene: https://medlineplus.gov/genetics/gene/mthfr/

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Thanks John! I’ll check into it! Sita

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@sita

Thanks John! I’ll check into it! Sita

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@sita I should have mentioned that I took the list of supplements and shared them with my primary care doctor to see if they had any problems or issues with me taking them. My primary care doctor at the time ran them by a Mayo Clinic pharmacist who said they thought the omega 3 and 6 supplement may be too much. After hearing that I had done some research on my own about therapeutic levels used for different health conditions and decided it was worth it for me.

Omega-3 Fatty Acids and Neuropathic Pain - Case studies demonstrate that oral intake of omega-3 polyunsaturated fatty acids from pharmaceutical-grade fish oil supplements results in pain reduction and functional improvement in patients with neuropathic pain.
-- https://www.practicalpainmanagement.com/treatments/nutraceutical/omega-3-fatty-acids-neuropathic-pain

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@johnbishop

@sita I should have mentioned that I took the list of supplements and shared them with my primary care doctor to see if they had any problems or issues with me taking them. My primary care doctor at the time ran them by a Mayo Clinic pharmacist who said they thought the omega 3 and 6 supplement may be too much. After hearing that I had done some research on my own about therapeutic levels used for different health conditions and decided it was worth it for me.

Omega-3 Fatty Acids and Neuropathic Pain - Case studies demonstrate that oral intake of omega-3 polyunsaturated fatty acids from pharmaceutical-grade fish oil supplements results in pain reduction and functional improvement in patients with neuropathic pain.
-- https://www.practicalpainmanagement.com/treatments/nutraceutical/omega-3-fatty-acids-neuropathic-pain

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Hi John, do you take all of the Protocol supplements? and fish oil plus hemp seed oil? and how much RAla do you take? I want to do a comparison as I do not do the Protocol but have always taken a lot on their list. Thanks, Helen

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@helennicola

Hi John, do you take all of the Protocol supplements? and fish oil plus hemp seed oil? and how much RAla do you take? I want to do a comparison as I do not do the Protocol but have always taken a lot on their list. Thanks, Helen

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Hi Helen @helennicola - Yes I take all of the Protocol supplements which includes both fish oil and hemp seed oil. The R-ALA capsules in the Protocol contain 600 mg Na-R-ALA but also combine some of the other supplements to reduce the number of capsules we have to take. The other supplements in the same capsule are 83.5 mg DFE Folate, 200 mg Magnesium, 4000 mcg Vitamin B12. This is in 2 capsules and the Protocol calls for 2 of these in the morning and 2 in the evening.

A card is included with the Protocol so that you can share the information with your doctor.

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@johnbishop

@sita I should have mentioned that I took the list of supplements and shared them with my primary care doctor to see if they had any problems or issues with me taking them. My primary care doctor at the time ran them by a Mayo Clinic pharmacist who said they thought the omega 3 and 6 supplement may be too much. After hearing that I had done some research on my own about therapeutic levels used for different health conditions and decided it was worth it for me.

Omega-3 Fatty Acids and Neuropathic Pain - Case studies demonstrate that oral intake of omega-3 polyunsaturated fatty acids from pharmaceutical-grade fish oil supplements results in pain reduction and functional improvement in patients with neuropathic pain.
-- https://www.practicalpainmanagement.com/treatments/nutraceutical/omega-3-fatty-acids-neuropathic-pain

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@johnbishop This from the NIH..
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828934/#:~:text=Harris%20cited%20extensive%20literature%20on,risk%20of%20aggressive%20prostate%20cancer.
Part of that study is as follows, "Harris cited extensive literature on fish intake and higher omega-3 fatty acid intake that demonstrated a lower incidence of prostate cancer incidence and death, better survival among men who already had prostate cancer, and a reduced risk of aggressive prostate cancer. Furthermore, citing World Foundation of Urology data,7 he noted that the incidence of prostate cancer is high in North America and Northern Europe (among Caucasians and African-Americans (63 and 102 per 100,000, respectively) but low in Asia. With the Japanese intake of omega-3 fatty acids at about eight-fold that of Americans and with their blood levels twice as high, one would expect a higher risk. However, the Japanese prostate cancer rate of 22.7 per 100,000 in 2008 was dramatically lower than the U.S. rates of 83.8 per 100,000.8"

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