Has anyone taken the targeted therapy osimertinib (Tagrisso)?

You will find it to be a lot simpler than chemo! And there could be some rash but it goes away. If you have any concerns I would be happy to talk to you about them. Glad you were foound suitable for this TKI. The new studies show very good results specially for 3 A patients. I am a 4C

I have been on Tagrisso for over a year. Now with Avastin chemo every 3 Weeks.

Why did you have to start chemo when you were already on Tagrisso?

Hello @lynnycooks and welcome to Mayo Clinic Connect- so happy you are here! This is a great place to connect with people with similar experiences and ideas. When were you diagnosed? If you are comfortable, can you tell us more about health journey? I'm looking forward to reading more of your posts!

I was diagnosed after 2 month of unusual headaches. Went for a CT and a large tumor was found.
Was sent to emerge where they scanned the rest of me and found a large lung tumor. Bam, stage 4 lung cancer. This all started on October 16, 2017.
First thing was brain surgery on Halloween of that year. I was on Tarceva for a year until it stopped working. Then was put on Tagrisso. That worked for about 1 year, Avastin chemo was added after Tagrisso was not working as well. Every 3 weeks I have an infusion. Makes me feel sick, not super bad.
I also had an xgeva bone shot every 4 weeks for the first time 2 years. I had another brain surgery on February 1st, 2019. That one slowed me down slot more than the first one. I had 3 bad month following it. Do ok now, I lack energy, don’t sleep well and always have a headache. But, I’m still alive!!!

My husband will be starting Tagrisso in 2 days. Stage IV, carboplatin and abraxane didn’t make impact after two treatments. We’re hopeful Tagrisso will help. He also has pleural effusion.

I have been taking it for the past 10months. Minimal side effects. Drink
plenty of water.

And I have been taking it for 28 months and minimal side effects and stable reports!

Hi @gigi123, I want to add my warm welcome to those you've received from @nursed2075 and @shaila1902.
Gigi, if my calculation is correct, your husband started Tagrisso (osimertinib) yesterday. As a targeted therapy for people with EGFR exon 19 deletions or exon 21 (L858R) mutations new hope. How are you both feeling about things?

Nursed and Shaila, what time of day did you find best for you for taking the once-a-day pill?

I prefer to take Tagresso just before breakfast at 8.30 am everyday. Its important to take it at the same time and not miss a dose so I have a double alarm set up on my phone for it. I have Stage iv Lung cancer with mets in brain since Feb 2017.