@katek001 Last year, I also did vancomycin for 10 days, then another Cdiff relapse so I did the Vanco pulse and taper for 6 weeks. Cdiff again returned three weeks later. I then took Dificid (fidaximicin) for 10 days and that's the RX that finally killed all the Cdiff spores. My GI also has me taking Florastor or any probiotic with S. Boulardii. I finished the Dificid last October and I still have days where I'll have loose stools. I think it will take a year or longer to ever feel "normal" again.