Anyone had prostate cancer spread to the lungs?

@rwski79 Have you considered Estradiol patch in lieu of Orgovyx?
Even less SE’s with the same level of T suppression.
The only caveat is your history of cardiac issues; but any form of ADT can exacerbate that, so talk to your MO about the pros and cons. Best, phil

@rwski79
Thanks, Richard. I know several people on the forum have had good results and low or no side effects with Orgovyx. Fortunately, I'm one of the lucky ones who've had no side effects with Lupron (other than ED which everyone gets, and weight gain with my first round of Lupron six years ago).

So far, I've had no side effects with either the Abiraterone or Lupron, and have so far avoided additional weight gain.

Now it's just a question as to how long the drugs will be effective before the cancer becomes resistant!

I've heard of another PCa patient with mets in his lungs. But he had a whole bunch of other mets elsewhere most in bones. For your PCa to go from remission to distant mets is very odd. Just as odd is passing over their natural habitat of the bones. No doubt, you are found these mets using PSMA PET scan. If you find any more, I would try Pluvicto which is recently made available to castrate sensitive men.

Yeah, there's almost no one else with my exact situation and very little literature about it. I'm not castrate sensitive yet, so hopefully the abiraterone and lupron continue doing their job for awhile. After that, I'm pretty sure Pluvicto is in my future.

@ctsenior Hi, my husband has mets in his lungs and nowhere else, but he has Cribriform prostate cancer which is aggressive and known for distant location mets too. Unfortunately for Frank he is one of the 3% of men who don't react to the PSMA pet scans radioactive material, so both his previous pet scans were negative. His lung nodules have been found by ordinary CT scan. Orgovyx and Abiraterone have worked so far in reducing his PSA as well as the larger lung nodules and the smaller nodules are no longer evident. Thankfully he's feeling great on his current treatment plan and will continue on it until the cancer becomes hormone resistant.
I've just checked and Pluvicto is not currently available in Wales, UK, but hopefully maybe by the time he could would need it.
Good luck with your journey 👍

@cher60
Sorry for butting in this conversation, but my dad was approved for Pluvicto after chemo, and one thing I know for certain is that mets need to be PSMA-avid to be even considered for Pluvicto. And as you just said you husband is amongst those with low PSMA expression, so Pluvicto definitely wouldn't be a part of his potential future treatments even if it becomes available in Wales...I hope he never needs any additional treatments ever🤞 Good luck to you both 🍀

@inconsolable Thanks so much for your reply; it's good to know about these added factors. We do know it will eventually return but are keeping everything crossed that it won't be for as long as possible. Good luck with your journey too.

Hi. I posted a reply a few weeks ago mentioning that I had surgery in August to remove two lung nodules. This was my fourth reoccurrence over a nine year period. At the time of surgery, the doctors weren’t sure if it was lung or prostate cancer. The final pathology report confirmed it was prostate cancer. Surgery was six or seven weeks ago. I just had my first PET scan since surgery and it was clean with a score of 0. There’s some smaller nodules that we are keeping an eye on, but nothing lit up on the scan today.

Hope this helps. Best of luck to you.

@florida11
When you say this is our fourth recurrence, were they all in the lungs?

No. This was the first time in the lungs. First was 10 months after surgery with radiation around the prostate bed, then was radiation for a lymph node around the abdominal area, then radiation to the hip bone.