Taking Eliquis and Metoprolol for A-fib: Concerned about side effects

Wouldn't it be great if all meds worked for all people.? I have had good luck with Meto but, like you, I know many others who are still looking for the right med. When I get a new med I try not follow up on it for a short while - otherwise I may develop issues based on what I read rather than on the good it is doing me. 'Mind over matter' for me, I guess.

Is that all you are taking?

I did not do well with the metoprolol. My problem(s) were kind of stumbly when I walked which wasn't too bad, but the worst was the feeling in my legs below the knee. I felt like this portion of my legs were just along for the ride. Pain and some numbness but just a feeling of not really working. Also, my heart rate was low for me. Sometimes in the very low 50s, but consistently in the mid to low 60s. I went off metoprolol about 2 months ago and the change in the feeling in my legs was almost instant. I had a successful ablation (PFA at UC Health in Aurora, CO) on May 23, 2025, and continue on Eliquis. Not so much for a blood clot due to a return of Afib, but because I am over 75 (86 on 09/12/2025) and at a +2 on the CHA2DS2-VASc Score.

I’ve been taking both Eliquis and Metoprolol for almost 10 years and haven’t had any side effects myself. But everyone’s different, so it can really vary from person to person. If you’re worried about dose or side effects, it’s a good idea to check in with your doctor before making any changes. Best of luck with your health.

I've been on metoprolol since my triple bypass in 2022.
Aside from getting the initial dosage right near the beginning (my HR dropped too low when combined with the amiodarone I was on at the time), I've had no issues with it.
I was on Eliquis for post-surgical Afib, but was taken off it after a couple of months. No issues.
I've recently gone back on Eliquis when my Afib returned at the beginning of July this year.
Aside from a possible initial bout of constipation which resolved, I haven't noticed any ill effects.
I've had the same experience with Eliquis and generic apixaban.

I take Eliquis and metropolol and started digoxin right before I had a cardio version back in July and all was well. At my follow up appointment, my dr. said to start taking the digoxin every other day, rather than daily. My Afib came back. He is now referring me to an electrophysiologist who is based in Nashville and only visits my town every other week. Anyone else had issues with digoxin?

@margreet - I have heard mixed reviews on Ablation and even the Doctor said it may only last five years. I am currently taking 100MG of Metropolol in the morning and 50MG at night. Still have bouts of AFIB. Eliquis was prescribed but was quite pricey.

I take both Metoprolol and Eliquis. I was given a coupon in the hospital for the first month free of Eliquis. Yes, it is very expensive. After reaching my deductible, $350, I pay $52 a month. I have been trying to get help since January with the drug company, but so far, nothing.

@xabbax
Once again you have too weigh the side effects of what ever route you take. Cost and side effects are part of those factors to consider.

@cad43
I'm sorry you still have to pay $52/month for this, but as drugs go today that is generally considered quite modest, and I think that's about 10% of the list price.

Let's see ... Google says that a generic version of Eliquis has been delayed several times by lawsuits and is currently scheduled for April 2028. Generally when this happens the list price is somewhat lower and most insurance paradoxically will pay a little more for it without dinging you just because it is "generic".