Has anyone else had emgality injections for migraines? Side effects?

Posted by lovelife4ever1 @lovelife4ever1, Nov 23, 2025

I have been on emgality injections for 3 months about to do my fourth one. I have had some side effects that my neuro dr says can't be from the injections. This is the only new med I have started in 4 months. Long story short, I have been very fatigue, high blood pressure, dizzy spells, ringing in the ears, and almost like sinusitis infection. About 2 weeks after first injection dr put me on antibiotics and steroids for a severe sinusitis infection and double ear infections. I felt better till I got the second injection now I have the same symptoms all the time some days or worse than others and some days are good. I also have back pain along with hand swelling for about a week to 2 weeks each time I get injections. My health insurance is very strict and my family dr has to refer me to specialist. What should I do or are these side effects normal. Yes my migraines are so much better than they were but I don't know if I can live with the side effects.

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I am still taking Emgality and it worked great for about 5 months now 18 months later I have more migraines than ever. No side effects.
I start Vyepti infusions tomorrow. You might try it. Apparently in clinical trials less than 2% of more than 1100 people stopped using it due to side effects. I will know more tomorrow.

Ask your Doctor about it.

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Profile picture for nannybb @nannybb

I was going to inquire for more information because I've never heard of this med. However, after reading side effects, I think I'll pass. I am curious as to what other meds. you have tried.

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I'm so very sorry that you went through all of that so many times. But I don't think it's a side effect of being injected with Emgality. Did you discuss all of these symptoms with your doctor? There's many other options you can try for your migraines.
I do the Emgality once a month, I have Ubrevly that I can take twice a day two hours apart. Daily I take Topiramate 200 mg twice a day and Keppra 750 mg twice a day because I also have Trigeminal Neulraga which is very painful.

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My son used emigality for 3 month as well he didn’t experience any side effects and I’m so sorry to hear that you are experiencing quite a bit , but ultimately he stopped the injections as the constant daily pain of electrical sensations all around his head just lingered on with no relief

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When it comes to medication side effects, I take the clinical trial results, sponsored by the drug companies, with a grain of salt. I inquire on ChatGPT or Gemini for "real world side effects , not clinical trials". There you can see what really goes on with drugs and what is reported with real users. In fact, sometimes AI quotes this very site. By the way, read about migraine injections in the real world. You will be surprised that "thousands" of users report severe anxiety, and panic attacks.

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For watch it’s worth, I

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Profile picture for laplume @laplume

When it comes to medication side effects, I take the clinical trial results, sponsored by the drug companies, with a grain of salt. I inquire on ChatGPT or Gemini for "real world side effects , not clinical trials". There you can see what really goes on with drugs and what is reported with real users. In fact, sometimes AI quotes this very site. By the way, read about migraine injections in the real world. You will be surprised that "thousands" of users report severe anxiety, and panic attacks.

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@laplume & lovelife4ever1
I have PTSD and panic disorder for years and under mental health care.
I tried Emgality for about 5 months and did not have not 1 side effect. Nothing.
Plus I noticed it did help reduce the # of monthly migraines.
However, I then felt it was losing its efficacy and stopped it.
Now I am thinking of going back on it again.
Sorry to hear of the side effects folks are having...awful!
I guess I was one of the lucky ones. It just reinforces all we know already.
Every drug works different on everyone.
Moving forward I wish you all the best!

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Hi! I’ve been on it for 6-7 months, I can’t say that it’s stopped how many migraines a month I have but, right after the shot the first couple may not be as intense.
I haven’t had any side effects that I’m aware of.

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Profile picture for lovelife4ever1 @lovelife4ever1

@nannybb I hope you find relief as well. Thank you!

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@lovelife4ever1 Google's AI: "19 sites Sinus issues—such as sinus congestion, pain, runny nose, or a sore throat—are also recognized side effects of Emgality."

I started with the two loading doses of Emgality almost a month ago. I am finding some improvement. I noticed elevated bp which let up after a week.

Interestingly, I've wondered why my sinuses have been congested. I don't know if it's connected but I'm using Arm & Hammer's saline solution to keep them clear & avoid an infection. Maybe that would bring you some relief.

Years ago, my doctor also told me to take the OTC expectorant, Guaifenesin, to avoid a sinus infection. I look carefully at the ingredients to avoid the added cold medicines. I know when I've found the plain expectorant because it's the inexpensive one! ☝️

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OMG! Thank you for your post. I have been having horrible knee pain in both knees, feeling like I'm getting ear infections, sinus issues, and like you,yes my migraines are so much better. I have had to miss work several times because I just feel so weak and can't figure out what's going on in my body.

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Never trust what a doctor says about drug side effects. Go on AI, or at least google to read about real world side effects...not what the drug companies report. It's a world of difference.

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