R-Lipoic Acid for neuropathy

I do appreciate your comments because it is true, most vitamins from the B group are good for neuropathy. I am having and injection of B12 every two weeks, vitamin B1, and I have vitamin B6 which is also good, but can also be bad for neuropathy. Today I ordered a blood work to see how it is.
I was told by the neurologist, after the EMG test, that the myelin in my tibial and peronial nerves were damaged beyond repair.
I am feeling much better with the treatment I am following.

I take 900 mg a day of R Alpha Lipoic Acid (R ALA). That is 300 mg three times daily. As a result, I have been able to reduce gabapentin dosage in half, from 2400 mg daily to 1200 mg. My mild diabetic neuropathy is now pretty well controlled. I drink at least 8 oz of water with each R ALA capsule to avoid slight upset stomach.

@cleveland26
Hi,
Have you by chance experienced any "facial flushing" as it's called? I take 200mg daily, because I JUST started this a week ago, and it seems to be helping my peripheral neuropathy in my feet (hands not so much) but I've been experiencing hot flash type feelings in my face.

Hi Nancy @nancysav, I've been taking 1200 mg na-R-ALA daily (600mg morning/evening) for quite a few years along with other supplements. I haven't experienced any facial flushing from the ALA but did find a research paper that mentions it.

"Results
The 600 mg dose was well tolerated. At the 800 mg dose, one subject had an intolerable flushing sensation. At the 1,200 mg dose, two subjects had intolerable upper gastrointestinal side effects and one subject had an intolerable flushing sensation. Subjects taking gastrointestinal prophylaxis medications had no upper gastrointestinal side effects.

Conclusion
High-dose ALA is not completely tolerated by the elderly. These preliminary data suggest that gastrointestinal prophylaxis may improve tolerability."
-- Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye: https://pmc.ncbi.nlm.nih.gov/articles/PMC5047711/

GoodRX has a list of medications that can cause the flushing along with some other causes - https://www.goodrx.com/health-topic/dermatology/why-is-my-face-red,

@cleveland26
Hi,
Have you by chance experienced any "facial flushing" as it's called? I take 200mg daily, because I JUST started this a week ago, and it seems to be helping my peripheral neuropathy in my feet (hands not so much) but I've been experiencing hot flash type feelings in my face.

@amota
Good luck with it. Isn't two 600 mg pills daily double the recommended dose?
I tried 600 mg daily and found no benefit.

Why are some people taking ALA at very high doses when the literature recommends 600 mg per day , why exceed that?

@amota
Hi, have you by chance experienced any "facial flushing" as it's called? I take 200mg daily, because I just started this a week ago, and it seems to be helping my peripheral neuropathy in my feet (hands not so much) but I've been experiencing hot flash type feelings in my face.