1. < Bariatric Surgery & Weight Loss
Profile picture for projfan

Switching from one GLP-1 RA to another?

Posted by projfan @projfan, Feb 13, 2025

I started on zepbound (tirzepatide) in a quest to reduce the pain of my knee arthritis -- buy time before replacing the joint -- which worked, but triggered a number of side effects that eventually became intolerable. Switched to ozempic (semaglutide). On the plus side, this really did reduce the side effects. (It helped that it's a multipen, which means I could click-dose.) On the minus side, apparently arthritis is emerging as a semaglutide side effect, and it may be one of mine. Everything else is going well, but the arthritis symptoms are coming back. So I'm thinking about switching again, if my orthopedist confirms that this is what's going on. I can go back to tirzepatide, or consider one of the older GLP-1RAs, like exanatide XR or dulaglutide. Or I could wait it out, and switch to a new product now in the pipeline when it becomes commercially available. Or I could get really creative, and alternate 6 months on semaglutide and 6 months on tirzepatide. Or something. Anyone else have experience with switching between these meds or thoughts on how to approach this problem?

Interested in more discussions like this? Go to the Bariatric Surgery & Weight Loss Support Group.

Profile picture for projfan
projfan | @projfan | Sep 26, 2025
In reply to @gbear1953 "@projfan Yes I agree I do not feel any symptoms yet and am aware of what..." + (show)
Profile picture for gbear1953 @gbear1953

@projfan Yes I agree

I do not feel any symptoms yet and am aware of what to look for. As I mentioned, I can test my glucose and of course will b aware of any stomach/bowel issues. As I read more, it does not seem to be a matter of great concern. My main takeaway was just how different the two injection pens work. Ozampic one can count to almost ten and as it slowly enters but Monjarno, Wow! it just jets into you.
BTW I will ask my MD to prescribe Monjarno when I see him next week as he had already suggested I try it because my A1C was kinda stuck at 6.9
G

Jump to this post

@gbear1953 You said you tried Victoriza. Isn't that a daily shot? What was the pen like?

REPLY
1 reply
Profile picture for gbear1953
gbear1953 | @gbear1953 | Sep 28, 2025
In reply to @projfan "@gbear1953 You said you tried Victoriza. Isn't that a daily shot? What was the pen like?" + (show)
Profile picture for projfan @projfan

@gbear1953 You said you tried Victoriza. Isn't that a daily shot? What was the pen like?

Jump to this post

@projfan I remember that it was a lot like Ozampic but daily.
By the way I have had no problems just I'm having bowel movement without using my usual laxatives.
I'm probably going to stay on Ozampic because I read it has heart benefits.
I'll ask doctor what he thinks.
G

REPLY
Profile picture for raos27
raos27 | @raos27 | Sep 14 11:44am
In reply to @max2 "I switched from OZ 2.0 to Monjaro a few months back. Started at 5 mg for..." + (show)
Profile picture for max2 @max2

I switched from OZ 2.0 to Monjaro a few months back. Started at 5 mg for 2 months, then 10 mg for same and am now moving to 12.5 mg. Good news was @ 10 of Monjaro, my A1C went from 6.8 to 6.2 without me making any changes. No weight loss over same period. I had RNY bypass 38 years ago. No problem with switching meds. My issue was on day six, Monjaro half life was over and I felt hungrier. It took another day after new injection for it to work again. I wish Monjaro had a screw top as the large gray plug is hard to refrigerate and carry enough when traveling for a few weeks. Best of luck to you.

Jump to this post

Hi @max2

Not sure if you found a suitable solution for your Mounjaro injection that helps you travel easily. I recently found this brand Eurolabx and you can keep up to 4 of these triangle pens in it safely. Just wanted to share in case you are still looking.

REPLY
Please sign in or register to post a reply.