Bone marrow biopsy: Was it painful?

Posted by conniekostiuk @conniekostiuk, Aug 7 6:56pm

I have a doctor at Mayo and a oncologist at UP Health System in Marquette Michigan. I have had one bone marrow biopsy at Marquette. I didn't feel a thing. Some people say the pain is bad for the biopsy. My doctor at Mayo, that I trust very much, asked where I would like to have the next biopsy, Mayo or Marquette. Has anyone had a bone marrow biopsy at Mayo? Was it painful at all? Thanks!!!

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Profile picture for Lori, Volunteer Mentor @loribmt

@twitt1949 That’s great news! I was thinking about you today and hoping it all went well. ☺️ Wishing only good news!!

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@loribmt I've had one biopsy. It was at hospital, it was so painful I want have another one. They gave me a local, I felt drill go through my bone and them drawing marrow out of bone and she did that twice, never again. I am seeing a new doctor this month and praying he does not want to do a biopsy because I can not do that again. I have a high tolerance for pain but that was the worst.

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Profile picture for hun8ln2026 @hun8ln2026

@loribmt I've had one biopsy. It was at hospital, it was so painful I want have another one. They gave me a local, I felt drill go through my bone and them drawing marrow out of bone and she did that twice, never again. I am seeing a new doctor this month and praying he does not want to do a biopsy because I can not do that again. I have a high tolerance for pain but that was the worst.

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Hi @hun8ln2026. Oye! You have me cringing right along with you, so I hope you won’t need another bone marrow biopsy. But sometimes they are a very necessary source of information for your doctor.
If you do need one, let your doctor know that you’d like sedation. You mentioned your last one was at a hosptial. So they are usually equipped to offer sedation. Just make sure to request it ahead of time.
There’s no stress, no pain and you wake up refreshed…usually to juice and a snack. Let me know what you find out, ok?

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Profile picture for wesleym @wesleym

I (74, male, dx high-risk MGUS/SMM) have had three BMBs in last two years, all in hem/onc's office with only local (no sedation). All three were no big deal, mostly vibration and pressure, maybe a second of tolerable pain. Drove myself there and back (only 15 minutes), one ibuprofen that day, no pain at all by the next day. I know there are people who swear by sedation, so YMMV.

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@wesleym
Same experience here. I have had at least two, I don't remember if there was a third. Each time was just injection to deaden the area and a little pressure and it was over. I have had tests that were a lot worse.
I guess the thought of them going into your bone and extracting a sample of marrow makes it sound scary and painful but not in my experience. No anesthesia was used or needed. Probably helpful to be relaxed.

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Just to be completely honest, while the procedure wasn't painful. The procedure left a big black/blue mark.....maybe 2-3 inches in diameter, which took a week to disappear, it didn't hurt, but looked terrible.

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Profile picture for Lori, Volunteer Mentor @loribmt

Hi @hun8ln2026. Oye! You have me cringing right along with you, so I hope you won’t need another bone marrow biopsy. But sometimes they are a very necessary source of information for your doctor.
If you do need one, let your doctor know that you’d like sedation. You mentioned your last one was at a hosptial. So they are usually equipped to offer sedation. Just make sure to request it ahead of time.
There’s no stress, no pain and you wake up refreshed…usually to juice and a snack. Let me know what you find out, ok?

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@loribmt thank you, yes I will ask for sedation next time. No one should go through that awake. Will let you know about visit with new doctor on September 15th. Thank you. 🙏

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I had my bone marrow biopsy at the iliac crest done by a nurse practitioner. They offered an Ativan orally beforehand. I shouldn't have taken it, because they wouldn't let me ride my bike home with the Ativan on board. The procedure was painless. Just a bit of a local lidocaine infusion at the site.
I was just overly worried.

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Patients have different experiences based on the center and practitioners within the center. I once held the hand of a patient while the head of this famous bone marrow transplant center attempted to do the biopsy. this otherwise stalwart friend screamed; it was horribly painful and he was clumsy. Later she found a NP at the same facility who was able to
Do a bmb that was tolerable. This center refused sedation for patients.
There are other centers that routinely use sedation. That would be my kind.
I have not had a bmb yet in 24 years and will avoid it if possible.

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Mayo rourinely uses sedation.

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