LDL-cholesterol and osteoporosis

Posted by WilWeten @wilweten, Aug 25 5:10am

I've started reading McCormick's book 'Great Bones'. He attributes his osteoporosis for the main part to too many MALPS, caused by a high LDL. He also says: "Couple this with a red blood cell count (RBC) below 4.0 million/mm3 and you probably have excessive MALP-production (see pages 46-47).

I searched and found e.g. this article from 2022: https://pmc.ncbi.nlm.nih.gov/articles/PMC8896571/ "High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20–59 Years of Age" .

That article links to this article from 2020: https://pubmed.ncbi.nlm.nih.gov/32163637/ "The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study."

By the way, despite McCormick's expectations, according to my google research, tocotrienols don't look effective in lowering LDL cholesterol.

For me, discovering that high levels of LDL cholesterol can form a significant contribution to osteoporosis, is an eye opener.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for WilWeten @wilweten

@reginacl Actually, I'm in Europe and my former GP refused to test me on LP(A), as "we don't do that, because we already know everything we need to know". I might ask my current GP at my next appointment...

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@wilweten

Boy, I wouldn't hesitate to seek info from another provider. That statement about knowing everything would send me flying out the door. Hope you find someone who is open to learning.

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Profile picture for WilWeten @wilweten

@reginacl Actually, I'm in Europe and my former GP refused to test me on LP(A), as "we don't do that, because we already know everything we need to know". I might ask my current GP at my next appointment...

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@wilweten
interesting, because I heard info saying once in a lifetime testing is standard in Canada and Europe.
The Lipidologist who I am a patient of did specialized blood testing which
indicated that “statins would not help lower my bad cholesterol” - Repatha is a newer injectable (every two weeks) treatment that helps lower the bad cholesterol.

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Profile picture for reginacl @reginacl

@wilweten
interesting, because I heard info saying once in a lifetime testing is standard in Canada and Europe.
The Lipidologist who I am a patient of did specialized blood testing which
indicated that “statins would not help lower my bad cholesterol” - Repatha is a newer injectable (every two weeks) treatment that helps lower the bad cholesterol.

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@reginacl What was the specialized blood testing they did to indicate that statins would not help lower your bad cholesterol? Sure would be great to find this out before starting statins...

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The blood work I had done on my first visit to the Lipidologist was sent out to Boston Heart Lab. It took two weeks to get the results back. Here is the link to the Lab info:
https://bostonheartdiagnostics.com/wp-content/uploads/2025/12/CVMap_Metabolics_Sample_RPT_T0331626_LR.pdf
I am attaching a picture to the part of my results that I believe the doctor pointed to when saying these results show statins would not help me.

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I agree with LP(a). I'm an avid exercise, normal weight and eat healthy. I have PVCs and went to see a cardiologist. He wanted to do a deep lipid panel as well as calcium score because my LDL was high. Lo and behold, my LP(a) is off the charts and I have 38% buildup of calcium. So upset, but he said it's genetic. I also have osteoporosis and degenerative disk disease. Correlation? Possibly. I'm currently on statins and Forteo injections. I tried natural supplements and nothing worked.

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Profile picture for reginacl @reginacl

Interesting how cholesterol can impact osteoporosis. At a Medicare checkup almost two years ago, I asked my GP if there were any blood tests to look at things like inflammation in my body. She said she would order a LP(a) test. When the results came back in the high range, that led to referral to heart doctor who ordered a cardiac CT scan that showed some calcium buildup in my LAN. Although that was not a high number, I was also referred to a heart specialist in Lipidology. From there was put on an every other week injection of Repatha.
When learning more about my LP(a) being elevated, found that one in five people have elevated LP(a), but doctors don’t routinely test for it in the U.S. They DO test for it in Europe and Canada. Since this elevated number indicates that the liver does not process cholesterol normally, which results in high bad cholesterol. Since you are making the association between osteoporosis and cholesterol, I’m wondering if the medical community is not making associations appropriately. If you knew there was a test that would show if you have elevated LP(a) that one in five people have, would you ask for it? Disappointed that this test that would show elevated LP(a) is not offered to patients (it’s a once in a lifetime, non-changing number). The U.S. needs to get onboard with Canada and Europe in LP(a) testing.

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@reginacl
What is LP test? I am living in Spain but do not have idea about it. However, I am doing extensive blood test a couple of times every year.

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Profile picture for melia7 @melia7

@reginacl
What is LP test? I am living in Spain but do not have idea about it. However, I am doing extensive blood test a couple of times every year.

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Profile picture for osteoprob48 @osteoprob48

I was surprised to learn this recently as well and that it seems to have occurred while using foods from Mayo Clinic to control my cholesterol that has been helpful. I take calcium, Vitamin D3 and recently started MK4 to address osteoporosis concerns. Would appreciate any further information/guidance on this issue.
Thank you.

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@osteoprob48 , protein is necessary for bone formation. Take any calcium supplements 2 hours apart from magnesium supplements and learn about other vitamin/mineral interactions if you take some. And exercise, exercise, exercise. Read the Liftmor research study if you haven't already. Adequate Protein is necessary for bone formation.
K-2 supplements, 5 prunes a day.

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Profile picture for reginacl @reginacl

Interesting how cholesterol can impact osteoporosis. At a Medicare checkup almost two years ago, I asked my GP if there were any blood tests to look at things like inflammation in my body. She said she would order a LP(a) test. When the results came back in the high range, that led to referral to heart doctor who ordered a cardiac CT scan that showed some calcium buildup in my LAN. Although that was not a high number, I was also referred to a heart specialist in Lipidology. From there was put on an every other week injection of Repatha.
When learning more about my LP(a) being elevated, found that one in five people have elevated LP(a), but doctors don’t routinely test for it in the U.S. They DO test for it in Europe and Canada. Since this elevated number indicates that the liver does not process cholesterol normally, which results in high bad cholesterol. Since you are making the association between osteoporosis and cholesterol, I’m wondering if the medical community is not making associations appropriately. If you knew there was a test that would show if you have elevated LP(a) that one in five people have, would you ask for it? Disappointed that this test that would show elevated LP(a) is not offered to patients (it’s a once in a lifetime, non-changing number). The U.S. needs to get onboard with Canada and Europe in LP(a) testing.

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@reginacl When I was 27, I had my gallbladder out. The physician told me that from now on, I had to be on a low fat diet because you need a gallbladder to help get rid rid of things. It acts as a filter. For some reason today, physicians don’t tell people that. I always have a lipid panel done because I have always had to watch my cholesterol. This test should be included in all bloodwork. If you have a normal lipid panel, getting tested it for that, it’s not necessary every year. A new drug was just approved by the FDA. I could never take statins. But for the first time, I am going to take Zetia, the pill form of the shots. Hoping to get the new drug recently approved by the FDA if I have any side effects on the Zetia.
Fiber psyillum husk supplements help lower cholesterol. I take those also.
Just my experience with cholesterol. You can control your cholesterol with diet by following the Mediterranean Diet.

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