Essential Thrombocythemia treatment with Besremi

@garyintlv that happens to me too

I have just had my 7th Besremi injection. I worked with Besremi directly when trying to get the medicine. You may want to contact them. They told me that they are working on a possible refrigeration solution themselves. I may buy this one you have here. I can't do anything for longer than 2 weeks at a time away from home. Look them up...Pharma Essentia manufacturers Besremi. FYI..side effects ok for now!!

@garyintlv

Unfortunately my liver levels decreased at a slower rate than they should have.
My hematologist told me to stop the Besremi and have an ultrasound scan and further blood tests before I see him again next week.

@garyintlv oh no. Im sorry to hear that. Hope the liver values resolve themselves.
How high were your liver values

@cariadk
ALT(GPT) was 166.
AST(GOT) was 102.

The values came down when I reduced the Besremi from 100 to 50mcg but the hematologist was not satisfied with the slow rate at which they reduced.
I'll see what he says next week.

@garyintlv
My current values are
Ast 94
Alt 85
My hematologist does not seem concerned. My dose is at 200 and my platelets have crept up again to 563.

@garyintlv
My ultrasound indicated fatty liver (I do not drink alcohol) and despite stopping Besremi three weeks ago, my liver results were worse.
My hematologist is sure that it is not the Besremi causing the issues, nevertheless I cannot restart until the liver issue is resolved.

He has referred me to a major hospital for an appointment with a hepatologist as soon as possible and warned me I may have to have a liver biopsy. Yipee.

I saw the hepatologist. He told me that according to the rule of thumb, enzyme elevations up to three times the normal level are acceptable. Besremi causes elevated liver enzymes in 20% of patients.
He sent me for a Fibroscan and some additional blood tests and subsequently confirmed I am ok to restart Besremi but needed to make sure my enzyme levels remain under three times the normal level (so 37x3=111).

I contacted my hematologist who usually responds immediately. I have not heard from him so I assume he is away on holidays. I have an appointment to see him in October (he attends a lot of conferences too and was not available before then).
In the meantime, based on what he told me at my last appointment, I have restarted Besremi at 50mcg.
He said we will increase it gradually and that he hoped a dose of 70 or 80mcg will keep the platelets within range and enzymes below the maximum recommended by the hepatologist.

Haven't heard of besremi as a drug for ET.
Hope all goes well with the enzymes.

@mdramsey48 sorry for the late reply as I was travelling in summer. The side effects I had from Besremi include itchy scalp and skin, lower WBC and Hgb. But now it seems both are improving overtime while platelet counts are well within the acceptable range.