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Has anyone had an exacerbation while on Brinsupri?

Posted by julieb28 @julieb28, Jul 20 6:53am

I have been taking Brinsupri since November. It so reduced the amount of phlegm that I stopped airway clearance. After a few months, I became short of breath with rapid heart beat. I thought it was a heart problem because I did not cough. It took many weeks to discover that I had a lung infection and tested positive for enterobacter cloacae complex, a resistant bacteria that did not respond to Augmentin but appears to have responded to Levaquin. I have been very sick, hospitalized twice after not being in the hospital for 20 years. I think the lesson I learned is that you have to do airway clearance when on Brinsupri even if you have less to cough up. I am recovering but still coughing up old blood from the infection. I would be interested to hear how others are doing on Brinsupri. Wishing everyone well.

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irenea8 | @irenea8 | 20 hours ago
In reply to @cyndanna "Yes, I have been on Brinsupri 25mg since February, and have had a wonderful five months..." + (show)
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Yes, I have been on Brinsupri 25mg since February, and have had a wonderful five months of not coughing and decreased sputum that only came up when I nebulized and huff coughed every day. Then, at the beginning of July, I slowly started coughing a little bit more, and sputum was coming up along with it. Nothing drastic, just a slow progression. Then I woke up with my lungs hit hard. Compromised breathing, heavy coughing, and a whole lot of green sputum. My Pulmonologist put me on doxycycline and prednisone for a week. (he didn’t want to put me on azithromycin without knowing what we’re dealing with so as not to create any more antibiotic resistance) It wouldn’t stop. I went to urgent care, and continued the doxycycline and three more days of prednisone. After a full 21 days of misery, the coughing has finally subsided, and the green sputum is only once or twice a day. Sputum samples show moderate pseudomonas growth. (I know I also have MAC and abscessus in there somewhere too as they have been positive in the past) So… not sure what role Brinsupri played is in all of this, but curious how the month of July would’ve gone without it. Praying I will be back to feeling healthy again for an extended period of time. It really was wonderful while it lasted.

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@cyndanna
Doxycycline is sometimes used to treat Pseudomonas but not usually.

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cyndanna | @cyndanna | 19 hours ago
In reply to @irenea8 "@cyndanna Doxycycline is sometimes used to treat Pseudomonas but not usually." + (show)
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@cyndanna
Doxycycline is sometimes used to treat Pseudomonas but not usually.

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@irenea8 Yes, it was a shot in the dark before sputum samples and to protect against antibiotic resistance. Urgent care prescribed Azithromycin but he said no. Not until we knew what we were dealing with.

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