Is there a connection between MGUS and Epstein-Barr viru?

I was very interested in your question. I also stumbled on to some vague association mentions between EBV and MM, but no real helpful information, but I have a similar very old situation. Did mention to my Hematologist, but no response. Had unusual lengthy and severe case of mono 65 years ago and many unsolved health issues in the years following, until I had an active Epstein Barr Virus titer confirm the cause in 1989. It was a new test to my doctor and only discovered after he had a new patient from Los Angeles move to our small rural area of the Midwest and my Doctor was able to learn info from the new patients doctors! Learned to manage recurring episodes. Then 2005 MGUS diagnosis. Monitored until 2025 and SMM. After more testing now in treatment for MM and Amyloidosis. Thankful for all the mostly good years I had without progression. I do hope you will also have a slow progression.

@piter 1
Pero no siempre hay progresion del MGUS a Mieloma o amyloidosis ¿ no? A veces se queda ahí, sin más ¿ no es así? y pasar una monocucleosis en la infancia predispone a tener MGUS en la edad adulta ?

I have the same question--does having mononucleosis in the past predispose someone to MGUS?

I had mononucleosis about 50 yrs ago (confirmed by testing).

I did read that a majority of people have been exposed to EBV. If so, then I guess it's logical that a subset of people with MGUS will also have latent EBV. In other words, maybe it's nothing unusual.

You may want to see my comments from 2 days ago. My mono as a young teenager was not a typical simple case of mono. But I do wonder about connections. I am currently in treatment for active MM and also Amyloidosis.

Hi mkd54, yes, I saw your comments. I'm curious, can you describe your "unusual lengthy and severe case of mono 65 years ago and many unsolved health issues in the years following"?

Mine seemed rather severe as well so I'm curious whether it was like yours. I was flat on my back in bed for at least a month. I couldn't do anything but lie there. I couldn't eat. I had fevers and my liver was compromised. I don't quite remember what the doctor told me about the liver involvement.

When I had mono I was only 14, and was pretty sick, much a blur so may have some incorrect memories. Flat on back in bed, as I recall about a month, also. My parents were told if temp got to 104 would have to be hospitalized, so I made sure they never saw those temps, but there were some. I missed so much school I was told may not be able to be promoted to next grade despite making up work and good grades, so I restarted life but only partial schooldays and no outside activities for months to follow. I have always had a crummy immune system and have often “caught” the usual and unusual and my illness would linger longer than for most people (both before and after mono). But I have had a fairly normal happy life and working in my main career job for 38 years before retiring. Luckily I found a great guy to share life with and I celebrated my 50th Anniversary right before my treatments began this summer. I learned to put energy into my responsibilities but cut out a lot of the extra activities to be able to keep going. I so appreciate that I am 72 and sitting here able to reflect on my blessings.