Advanced Prostate Cancer

Pluvicto was designed to treat people with multiple metastasis. If you don’t have multiple metastasis, they will not use Pluvicto.

Chemo was designed to do the same thing, but it is a little harder on the body.

@jeffmarc thanks

Radiation Oncologist recommending pluvicto 6 cycles with a PICC to be used and removed after each cycle. Is this normally done? Have others had a picc line inserted and removed the same day as the infusion?
I have stage 4 prostate cancer Gleason score (4+5), on ADT (Eligard + Osenvelt injections, finished Taxotere. PSA was 3.0 and is now rising to 6.76

@diybiker
I never heard from members that special port is needed for Pluvicto and when I Googled it was stated that regular IV is usually used since it helps nurses observe the line and what is happening with radio active material, but maybe your center uses PICC. I personally would ask why they use PICC wen it is not standard of care .

Wishing you the best of luck with your treatment and may it bring your PSA to undetectable level 🍀. Let us know how it went : )

@diybiker
I have never heard of Pluvicto either PICC being done. It sounds to me like you are not in the USA or Canada.

The Eligard + Osenvelt injections are another thing I’ve never heard of combining together. Osenvelt Is Denosumab which is very common to use with somebody that’s had ADT for a while and has bone deterioration. Your case appears to have metastasis to the bone and they are giving you that in order to prevent bone deterioration in those areas, As well as the rest of your body.

Eligard Should bring down your PSA, And the Pluvicto Can treat the spots that have metastasis.

Hopefully, that will give you some longer-term relief in a few sessions.

One of the biggest problem is that Pluvicto doesn’t work well for everybody, About 1/3 of people that get it don’t get any benefit. Hopefully, you are among the other group.

@diybiker this sounds like a highly unusual and unwise plan. My husband had six Pluvicto infusions in 2024 at Mayo Rochester. They never mentioned having a PICC implanted. I would think putting one in and then taking it out six times during the course of treatment would be exposing the patient to unnecessary and potentially dangerous procedures. Ask the treatment team why they propose PICCs and whether a regular IV is possible instead.

@diybiker, I'm wondering if they were referring to the IV line. As others have said, Pluvicto is usually administered directly into a vein as an intravenous (IV) infusion or injection.

A peripherally inserted central catheter, also called a PICC line, is used to deliver medicines and other treatments directly to the large central veins near the heart.

A a PICC line might be recommended if a treatment plan requires frequent needlesticks for medicine or blood draws. A PICC line stays in place typically for the length of treatment and is not removed after each treatment session. Once the PICC line is in place, it can be used for other things too. PICC lines are sometimes used for blood draws, blood transfusions and contrast material given in a vein before an imaging test.

@diybiker, were you able to get clarification from the radiation oncologist about how Pluvicto will be administered for you? Did you start treatment yet?

I sent an e-mail to my radiation oncologist last Mon. 7/20/26 with my questions as to why he is using a PICC line and not a standard IV. I have finished 5 cycles of chemo/Taxotere and the oncology nurses had no problems with my veins and starting IVs. I am meeting with another radiation oncologist this week to get a second opinion on this unusual use of a PICC line.
I will update when I receive more information.

tonno
I had a psa of 240 and have metastatic stage 4 ,been on adt for over 2 years.
a break from meds .I am getting mixed advice.Anybody have any similar experience

@tonno
You don’t tell us anything about your actual medical situation.

How long has your PSA been undetectable?.

How high was your Gleeson score?

What treatments did you get?

Were any of these things found in the biopsy intraductal, ductal, large cribriform, Seminal vesicle invasion, EPE or ECE. (Extraprostatic extensions extra capsular extensions). They can make the cancer much more aggressive.

Did you get genetic testing and do you have any genetic issues?

Have you only been on ADT or you have you also been on an ARPI?