Has anyone experienced fatigue while taking Mirtazapine?

Yes, it is a definite side effect. I was on mirtazapine 30 mg. years ago & at that time a life savior for me.
I had suffered a very traumatic event and could not sleep or eat (or do anything really). However I was not hospitalized. After lots of trial and error with other SSRIs it was this drug - a SNRI - that help me sleep and gave me an appetite. However, be aware...this drug can/will caused major weight gain along with increased lipid profile and triglycerides. Eventually I had to go on the statins, my cholesterol, etc. became so high. But I needed this medication at this time in my life - it was the only medication that returned me to a "normal" life and I was able to go back to work, etc. & become fully functional again.
I took it at 9 PM nightly. In time, if you are on it for "long" term your body will eventually adjust to it and your fatigue will not be so pronounced.
Hope it is helping with your depression. All the best!

Thanks for your reply. I also take Wellbutrin which helps to control the weight gain.

I’ve been on Mirtazapine for a long time now, and I do experience fatigue during the day - but I have chronic fatigue syndrome, so not sure how much of it is related to the Mirtazapine. I have to take it for chronic insomnia. I have not experienced weight gain or elevated lipids, but I take over 20 prescribed meds, so they may be helping prevent those issues.

@briarrose I take it for sleep , specifically! It also helps me with my anxiety and depression.

Do you take 30 mg?

@bern7475 what dose do you take for sleep ?

@crbarefoot 7.5. I’m really sensitive to medication so a little goes a long way ! I was on 15 and I was like a zombie! It works really well and I don’t feel like a zombie!

@bern7475 that is great! Do you mind me asking if you were on it for anxiety or insomnia?

Mirtazapine has a paradoxical effect in which the lower the dose the more sedating it is in general. In other words and according to my doctor and the pharmacist I consulted when I tried it, anything OVER 15 mg becomes less sedating. I tried both 15 mg and 7.5 mg and they both completely left me too fatigued and sleepy the next day. But I have always been sensitive to meds. I was using it for sleep and anxiety. I could not continue with it because I had to be able to function the next day. The pharmacist could not tell me if 22.5 mg would still work for insomnia but not leave me so wiped out the next day and I was too scared to try it. I had read in reviews that a lot of people had tried 3.75 mg (half of a 7.5 mg pill) and it still helped them sleep, but with the paradoxical effect of more sedation at lower doses I was too scared to try it. The first time I ever took it I had only been sleeping 2 hours a night and I slept for 14 hours. No side effects except for being spacey and tired the next day. That was 6 years ago. I tried it one time again last week and the after effects lasted two days this time but I am now 72 years old and even more sensitive to drugs. Only tried it one night this time! Yes (sigh) I have had insomnia for 6 years now with an average sleep of 4 hours a night. Sleep apnea ruled out. I am currently trying Ramelteon and have literally been through all the common sleep meds which either didn’t work or had too many side effects. Ramelteon apparently is not an instant sleep med and can take days or weeks to be fully effective so I will post back with my experience. Luckily no side effects with it and my dosage is 8 mg. Had to find a psychiatrist with more drug side effect knowledge than my GP doc and was blessed to find an amazing lady in Corpus Christi who is so patient and knowledgeable. Insomnia is the most difficult thing I have ever dealt with and my heart goes out to anyone experiencing it. Keep your chin up and remember to take it one day at a time. Also remember that you have made it this far and that the answer may be right around the corner.

Have you tried cannabis I us gummies for sleep?