Can anyone share their experience with Nubeqa (darolutamide)?

Is yours metastatic?

I take a shot every 3 months along with nubeqa. I'm like you I'm thankfully for every day. Do you have any pain anywhere? My psa dropped from 53 to 19.

Wow! Three years. I thought I was long at two years. Started when I did chemo, soon after I started Lupron injections. Stopped Lupron after 13 months. So I’ve been on Nubeqa monotherapy for almost a year. Primary side effects include gynecomastia and fatigue, especially in my legs. My PSA has stayed negligible while my T has risen to 350.

Only bone aches and bad fatigue. I wish you well in your treatments.

I have been on Nubeqa for about 3 years plus ADT. I'm denovo stage 4 metastatic to the bone only. PSA is undetectable. Just had a PSMA-PET on 10/6/2028. Results - "No evidence of regional or distant metastases with PSMA uptake." All bone metastases have no abnormal PSMA uptake. Nothing in the lymph or organs.

Had a bone scan on 06/04/2025. Results "Interval Improvement - Decreasing tracer activity in areas of known bone metastasis with no evidence of disease progression."

Nubeqa does not cross the blood brain barrier - so no brain fog. ADT + Nubeqa does however produce hot flashes. Some are just terrible.

Everyone is different, but I think Nubeqa continues to test out better than the other ARSIs with regard to Overall Survival, time to castrate resistance, and time to pain. By the way, the ARASENS trail still data still lists time to castrate resistance as Not Reached (NR).

Do not let any doctor tells how long one can live with this disease. They do not know. Everyone is different. Every cancer in each of us is different. Everyone's ability to handle treatment and how much are different.

I chose to carpet bomb the cancer upfront. Radiation to the spin (10 cycles) and ribs (5 cycles) first to shrink the metastases, Casodex for a month, ADT and Nubeqa, Xgeva, and 10 cycles of chemotherapy. I would have done 2 more cycles if my doctor would allow it.

I was diagnosed with De nova metastatic prostate cancer June 2022. After Radiation treatments to my spin and ribs and 30 days on Casodex, I started qurterly Eligard injections and montly Zometa infusions. Along with Eligard and Zometa, I was started on Chemotheropy and Nubeqa (Darolutamide). So, I've been on Nubeqa (Darolutamide) almost 2 years. It is a miracle drug. I highly recommend that you do triplet therapy and take Nubeqa. All studies show that Nubeqa works better than all the other ARI drugs such as Enzalutamide or Apalutimide. The others are great but none has tested better than Nubeqa for Overall Survival and time to Castrate Resistance. To date, time to Castrate Resistance when taking an ADT, Nubeqa, and Docetaxel (chemotherapy) has not been reached. It has been over 5 years since the ARSENS trial ended. Nubeqa also does not break the brain blood barrier so you will not have continued fogginess or forgetfulness. I am a high end Software Developer/Architect and it does not affect me cognitively at all. The ADT (Eligard) and Nubeqa do give me terrible hot flashes. But, that is a trade-off I am willing to accept. If you are chemo healthy and you feel you can handle more than 6 chemo treatments, I recommend you do so. I did 10 treatments. But everyone is different and can handle what they can handle. The increased chemo treatments also increases Overall Survival (OS). The more micro metastases you kill up front, the better chance you kill any cancer cells with other mutations. The only treatments the doctors offer to kill the cancer is radiation and chemo. ADT and Nubeqa stop the creation of testosterone which the cancer feeds off. So, in my mind I wanted to Carpet Bomb the cancer with radiation and 10 chemo's. Had my doctor agreed, I would have done 12 cycles. But, I was able to handle it, because the Lord Almighty made it so I could. For that, I am thankful. Lastly, I will say the more chemo treatment the longer the recovery. I am just now starting to feel more energy. I do not need a nap in the afternoon anymore. My PSA is undetectable and my latest bone scan showed no evidence of cancer (rather stable metastatic disease). God Bless You. Be healed in the name of Jesus.

May I ask how your bone metastasis was diagnosed???

experience in Darolutamide used for treating your Prostate cancer