Having Wegovy digestive issues ?

I’m not taking the medication Wegovy but I have heard that some people experience digestive problems with it, I noticed that you were taking probiotics and also Benefiber which I have taken before. I remember that they both gave me a lot of digestive issues especially probiotics, Benefiber works like a laxative if you take it for a while, it’s very similar to Metamucil which is another high fibre supplement. The probiotics were the hardest on my stomach, this is a known side effect, if you’re having diarrhea then it’s probably one or the other that might be causing your problem. I think it’s best to either speak to your doctor about this or ask a pharmacist about your symptoms, you may just need a change in dosage or perhaps consider another option.

Thanks, I appreciate that. I will for sure follow up with the doctors for the best solution. I am and have been taking Famotidine and Pantoprazole as well.

I have been approved for Wegovy but was afraid to take it! The digestive issues scared me. Would you say the results are worth the aggravation? I guess I could try it and always quit if it causes me too much grief. I eat pretty well but my weight keeps increasing. It scares me.

Thanks for the comment. I've been on the medication for close to three months. So far, I would say the benefits do outweigh the potential digestive issues. I am a heart patient as well as needing to shed some weight. That was important to me. Im trying to find the right mix of digestive solutions to combat some constipation, etc. I'll post my success or failure as I move thru this process. I guess each person's situation is different, based on their own personal health and objectives. Im planning on continuing to work with my doctor and gastro doctor to get where I need to be. If I can, fantastic, if not, I'll just discontinue the medication.

@mayomee that’s how I feel. A little apprehensive because I try to keep my digestive system calm. I will be starting Wegovy next week. Fingers crossed! I would like to know how it goes for you as well. I had a heart attack a few years ago.

I had digestive issues in spades the first time I took semaglutide (Wegovy) two years ago. It worked well - lost 53 pounds over the time I took it - but the digestive issues ultimately got to be too much.

I had doubled-over cramps and churning in my gut, nausea and chronic diarrhea. I also had what my family called "death burps," which were foul enough to bowl over everyone in a family car or anyone near me while sitting on our couches watching a streaming show with our family.

The worst of it was fecal incontinence and random vomiting.

The fecal incontinence happened in bed at home and then in a cruise ship bed. Just mortifying, humiliating. The reason for this was basically runaway diarrhea. At home, I started using bed pads for confidence sleeping, though those two instances were it, thankfully.

The random vomiting mostly occurred at home in our toilets, often in the mornings. I eventually had several incidents of random, uncontrollable vomiting in the car. Three times this occurred when we could not instantly pull over for me, and I made a mess in one of our vehicles. One of these times made us late to a play we were attending, as we had to go back home to clean the car and for me to clean up.

Another time I was in a choir room on Easter Sunday, and it hit me so hard I could not make it to a restroom that was not real close to where I was. I vomited on the carpet right in the middle of our large church's back lobby on Easter.

I also got hit with the urgent need to vomit on a 5-hour trip mostly on an interstate to see my in-laws. We couldn't pull over, so my husband told me to vomit out the window. Evidently I lack skill in this, cause I guess my head wasn't far enough out the window, and the wind blew the vomit back in the window and sprinkled everyone in the car.

My insurance didn't cover me past that year, and I had asked to be switched to another glp-1, which didn't work well for me or have time to really work for the rest of that year.

The solution for me has been how these shots are being customized to me now that I'm taking them again in 2026, since I have insurance coverage again. I am taking each dose for 3 months so my body can accustom to it. This has been maddeningly slow for weight loss purposes, but my side effects have been extremely minimal.

@gmarosie
Thanks for your note. Good luck on the medication. Everybody's situation is different of course and I would make sure you let all of your medical providers know you're going to start taking Wegovy. I had mixed experiences while taking it. I lost around 15 to 20 lbs in the 90 days or so I was on it. That was great. Its very important to follow the directions given, especially about taking it on an empty stomach, and not eating for 30 minutes after taking it first thing in the morning. I wouldn't eat the evening meal the night before after 6 or 7 pm and try to go to the bathroom before bedtime. You will need to eat small meals, and try to exercise more. The only time I had any digestive issues ( diarrhea and stomach aches) where when I ate too much and maybe too late the night before. I've been off of it now for a few weeks and have not gained any weight back, probably because Im eating less and eating better food. I would try it, but big emphasis on less caloric intake before and during the dosage. You will lose weight and be less hungry as you go. The positive heart component is a plus. If you can minimize and manage the digestive symptoms you may or may not incur, hopefully you will have a good experience. Good luck.

By the way, I was taking the pill. Low dose for about 2 months and 4 mg for about a month.