Thanks for the comment. I've been on the medication for close to three months. So far, I would say the benefits do outweigh the potential digestive issues. I am a heart patient as well as needing to shed some weight. That was important to me. Im trying to find the right mix of digestive solutions to combat some constipation, etc. I'll post my success or failure as I move thru this process. I guess each person's situation is different, based on their own personal health and objectives. Im planning on continuing to work with my doctor and gastro doctor to get where I need to be. If I can, fantastic, if not, I'll just discontinue the medication.