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Psa levels
I read an article that a new study show that an undetectable Psa level is not a true predictor of cancer not spreading that routine imaging should be done. Is anyone familiar with this new study.
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Actually, a study about this was done well more than a year ago. They found that even if you had an undetectable PSA, you could still have metastasis grow.
Here’s a link to an article from 2007 about it.
https://pubmed.ncbi.nlm.nih.gov/17171704/
Here’s another article from 2022
https://pmc.ncbi.nlm.nih.gov/articles/PMC12984609/
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1 ReactionSo i guess having a undetectable psa doesn't really mean anything. So what do you do just wait until you have symptoms. A pet scan can't be done that often.
Well this is a kick in the nads. I had it in my mind that undetectable PSA was the gold standard for knowing no recurrence. Guess the BCR odds really are not that important, instead only odds of death by PCa are reliable?
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2 ReactionsWell I'm thankful that I've gone this long and every day is a gift from God to be treasured. So like that commercial on TV let's start living
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2 ReactionsYeah, I was pretty happy 15 months post-prostatectomy staying undetectable. A friend that encouraged me to deal with my prostate had been undetectible after his surgery for 5 years. He just told me last week that his PSA has just started climbing and he is meeting with doctors to decide his next step. I guess it's why doctors don't tell us we're cured because they don't really know, and I may have gotten lazy about continuing to get that simple little test.
Hope they didn't get his lab work mixed up with someone else's.
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2 ReactionsWell I wandered since my pet scan didn't show anything why couldn't you stop the meds. I was told that the cancer cells can be "dormant" and you can become castrate resistant. Well i have a good oncologist and just think they don't tell you the whole story; but I understand that to a certain degree
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1 Reaction@jeffmarc Yes, disease progression does occur with no PSA but most of those identified had very advanced prostate cancer prior to the no PSA progression with 95% metastatic (69% castrate resistant), 67% with prior chemo. The 93% on ADT w/77% ARSI might also have something to do with the undetectable PSA. It appears that this should not be very concerning to the typical patient that had RP or RT as a first treatment. It is very unlikely that if they have a first recurrence it will not be detected by PSA.
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2 Reactions@jim18 That sounds reasonable to me. Thanks!
It seems that there are a lot of theories floating around on finding prostate cancer. Here is an article I just got an email on titled: PSMA-PET-CT May Allow Some Men to Skip Prostate Biopsy and a link. I don't think I would trust it, but these are articles they send out to doctors and PAs.
https://www.medscape.com/viewarticle/psma-pet-ct-may-allow-some-men-skip-prostate-biopsy-2026a1000m68
Here is another I found interesting, but also confusing. https://www.medscape.com/s/viewarticle/proton-therapy-prostate-cancer-what-should-clinicians-do-2026a1000m94
What is RP and RT? Well headed to bed goodnight all zzzz