@jeffmarc Yes, disease progression does occur with no PSA but most of those identified had very advanced prostate cancer prior to the no PSA progression with 95% metastatic (69% castrate resistant), 67% with prior chemo. The 93% on ADT w/77% ARSI might also have something to do with the undetectable PSA. It appears that this should not be very concerning to the typical patient that had RP or RT as a first treatment. It is very unlikely that if they have a first recurrence it will not be detected by PSA.