Anyone on Pluvicto? Looking for a support team

We discovered Pluvicto didn't work for my husband because
Of a specific genetic mutation causing cancer to be more aggressive. While it limits options for him, the genetic testing he had was a good idea. Helps determine immunotherapy options and which drugs or drug combos might be most effective. Good luck with your journey

Howdy All,
I've completed 2 cycles of Pluvicto and due for a third early July. This was necessary because, after 5 years of treatments...radiation, chemotherapy, ADT all this time and negative on scans for 2 years, the cancer metastasized yet again.
I've been fortunate to handle all phases fairly well, except for CV issues with Eligard which I then changed to Firmagon.
Pluvicto is a different beast...The main side effect I experience is EXTREME fatigue (not just "fatigue" as advertised...LOL). All important blood levels have remained consistently within normal range, but after the second treatment the PSA went down 67%. Very good, and makes the fatigue worthwhile....
However, I did suspend ADT (Firmagon) because I was having more CV issues...shortness of breath, high ventricular rate, PVCs, etc. (This was against my Oncologist's advice, but I know my body.) In addition, I don't know if Pluvicto amplifies the "brain fog", but it sure seems like it....Reports say cognitive functions generally return to normal after about 3 months after ceasing ADT.........but I may have to return to ADT.......

In closing, I've had good results certainly justifying the change in lifestyle. As someone previously alluded to, I say "I'd rather be tired than dead"...a rather blunt reality check!

Blessings to all

I was a Pluvicto clinical trial patient for Norvartis Pharmaceutical in 2021-22, receiving rounds. It was my wonder drug and had virtual very little fatigue at any time. Upon the return of the prostate cancer about 2024, I have repeated 4 of the 6 rounds, through a very special arrangement. Again, I responded remarkably with only little fatigue. As others have said, each person reacts differently. I absolutely stay as active as I can with life, including competitive tennis, biking and daily life with family. I eat well and get adequate sleep. For me, this lifestyle as played a hugh role in my response to Pluvicto and fighting off fatigue.
Good luck with what you and others are going through.