Is a Spiculated lung nodule always malignant?

Posted by darwin66 @darwin66, May 16, 2023

Hello,
58M, Nonsmoker, No history of cancer
I went to a pulmonologist due to coughing, shortness of breath for over 2 years and got diagnosed with allergic asthma.
Ct scan showed 5 lung nodules all on the right lung.
2 are calcified -most likely granuloma,
2 perifissual- which are most likely benign
1 subpleural nodule 5mm
1 spiculated nodule 5mm
The spiculated lung nodule worries me the most
I did research and all data and studies say that spiculated nodules are malignant with a predictive value of up to 90% ..
Doctor wants to just monitor it with follow up Ct scans.
I read that in rare cases infections, Inflammation or sarcoidosis can have Spiculation but Generally such nodules are a sure sign of Malignancy.
Anoyone on here who has experience ?

Interested in more discussions like this? Go to the Lung Health Support Group.

Profile picture for hercules @hercules

@sharynlynn hello, thank you so much for taking the time to reply and share your experience! It was just what I needed to hear today. I am so happy that yours resolved after two annual ct scans! I have been praying so hard for my case to be the same.. I am praying they will not only be benign but just be completely gone as well! I am thankful for early detection and screening but I stay on the struggle bus with the anxiety of the wait and watch process. Thank you for the encouragement! Wishing you the best health!

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@hercules Will add you to my daily prayer list. God bless

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Profile picture for sharynlynn @sharynlynn

@hercules Will add you to my daily prayer list. God bless

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@sharynlynn thank you so much that means a lot to me and is very kind of you, bless you! My name is Sabrina and I blessed for you to pray for me.

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Profile picture for junerose42 @junerose42

@363 Good news! I had the follow up scan in January after having the CyberKnife radiation on my lung nodule. The scan showed that the nodule had been reduced to scar tissue. I have another follow up scan to be done in July. I'll report the results here. The fact that mine was "spiculated" and had also grown some since first discovered in 2017 resulted in my decision to have the CyberKnife radiation treatment. Since deciding on radiation over surgery at age 83, I've attended a seminar with a lung surgeon at my local hospital whom I found very kind and impressive. He said that he did lung nodule surgeries on many patients in their 80s, and that they were up off the operating table and walking down the hall soon after their surgeries. He did the surgery with the Da Vinci Robot. Thus, I wouldn't rule out a surgical procedure if you choose that over radiation. But I hope you won't need either.

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@junerose42
Wonderful news! Thank you for sharing with us!

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I'm a never smoker, unknown family history (adopted), 62 y/o, female otherwise reasonably healthy until a recent coronary artery calcium score CT scan on 04/2026 identified a 2 cm nodule in LLL; I had a CT with/without contrast back in December for a small intestine block which only called out consolidation in the LLL. 6/4, I had a pet scan showing nodule SUV 1.8; my pre biopsy CT 6/12 showed stable solid non-calcified peri-bronchial nodule with associated focal architectural distortion and spiculated margins measuring 2.4 cm. There are several other solid non-calcified and ground-glass nodules scattered throughout the lungs, largest in the anterior sub-pleural right upper lobe measuring 7 mm. My pulmonologist is working it up assuming it is malignant with baseline blood work for genotyping. I had a Nodify (Biodisix) blood test that suggested <4% risk for malignancy but the morphology of spiculation wasn't called out at that time so not sure if Biodisix included that feature in their risk algorithm. I will have the results back from my biopsies (nodule and nodes) in the next several days. I am very happy to find this group for support and additional information sharing - it's hard to take it one day at a time, try not to meltdown emotionally, and helpful to not be "alone."

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I think the hardest thing next to hearing you have cancer is waiting for the workup tests. You seem very educated in the terminology. Perhaps the most important test is the “liquid biopsy” Guardant 360, a lab in California, that tests for types of genetic mutations, which can each be treated with different drugs. EGFR is the best to have. TAGRISSO I believe is the drug. There’s also new CAR-T trial at Penn for EGFR. My husband has ERBB2, and was the first patient at Penn to receive a newer drug, zongertinib marketed by Boehlinger Ingersoll as “Hernexeos”. I found out about this drug by using ChatGPT. You can even copy & drop in scans or written conclusions. I asked the oncologist if we could try it, and it cleared the cancer in his lungs and all of his organs. A daily miracle pill. If you were never a smoker, and no family history, then you may have a genetic mutation- different than genes from ancestors.

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Profile picture for peg1224 @peg1224

I'm a never smoker, unknown family history (adopted), 62 y/o, female otherwise reasonably healthy until a recent coronary artery calcium score CT scan on 04/2026 identified a 2 cm nodule in LLL; I had a CT with/without contrast back in December for a small intestine block which only called out consolidation in the LLL. 6/4, I had a pet scan showing nodule SUV 1.8; my pre biopsy CT 6/12 showed stable solid non-calcified peri-bronchial nodule with associated focal architectural distortion and spiculated margins measuring 2.4 cm. There are several other solid non-calcified and ground-glass nodules scattered throughout the lungs, largest in the anterior sub-pleural right upper lobe measuring 7 mm. My pulmonologist is working it up assuming it is malignant with baseline blood work for genotyping. I had a Nodify (Biodisix) blood test that suggested <4% risk for malignancy but the morphology of spiculation wasn't called out at that time so not sure if Biodisix included that feature in their risk algorithm. I will have the results back from my biopsies (nodule and nodes) in the next several days. I am very happy to find this group for support and additional information sharing - it's hard to take it one day at a time, try not to meltdown emotionally, and helpful to not be "alone."

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@peg1224 you are doing everything right..and the fact you have had biopsies will give you the answers and praying that they are non cancerous growths.

Please keep us informed if possible and wishing you all the very best

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Profile picture for peg1224 @peg1224

I'm a never smoker, unknown family history (adopted), 62 y/o, female otherwise reasonably healthy until a recent coronary artery calcium score CT scan on 04/2026 identified a 2 cm nodule in LLL; I had a CT with/without contrast back in December for a small intestine block which only called out consolidation in the LLL. 6/4, I had a pet scan showing nodule SUV 1.8; my pre biopsy CT 6/12 showed stable solid non-calcified peri-bronchial nodule with associated focal architectural distortion and spiculated margins measuring 2.4 cm. There are several other solid non-calcified and ground-glass nodules scattered throughout the lungs, largest in the anterior sub-pleural right upper lobe measuring 7 mm. My pulmonologist is working it up assuming it is malignant with baseline blood work for genotyping. I had a Nodify (Biodisix) blood test that suggested <4% risk for malignancy but the morphology of spiculation wasn't called out at that time so not sure if Biodisix included that feature in their risk algorithm. I will have the results back from my biopsies (nodule and nodes) in the next several days. I am very happy to find this group for support and additional information sharing - it's hard to take it one day at a time, try not to meltdown emotionally, and helpful to not be "alone."

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Welcome to Mayo Connect @peg1224 , Waiting for results can be one of the most difficult times in the diagnosis process. It sounds like your pulmonologist is taking steps to take good care of you, in nailing down what these are at the cellular level. While it's difficult to wait, each step in the process is helpful to form the full picture of what's happening. And more importantly, what to do next.
I know it's hard but try to keep busy to keep your mind on something else. Those 'meltdowns' are understandable too. You're allowed to be scared, but also know that there are so many good treatments available today for lung cancer. Your docs are on top of this. Please let us know when you get more information on the tests. Hugs.

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Profile picture for peg1224 @peg1224

I'm a never smoker, unknown family history (adopted), 62 y/o, female otherwise reasonably healthy until a recent coronary artery calcium score CT scan on 04/2026 identified a 2 cm nodule in LLL; I had a CT with/without contrast back in December for a small intestine block which only called out consolidation in the LLL. 6/4, I had a pet scan showing nodule SUV 1.8; my pre biopsy CT 6/12 showed stable solid non-calcified peri-bronchial nodule with associated focal architectural distortion and spiculated margins measuring 2.4 cm. There are several other solid non-calcified and ground-glass nodules scattered throughout the lungs, largest in the anterior sub-pleural right upper lobe measuring 7 mm. My pulmonologist is working it up assuming it is malignant with baseline blood work for genotyping. I had a Nodify (Biodisix) blood test that suggested <4% risk for malignancy but the morphology of spiculation wasn't called out at that time so not sure if Biodisix included that feature in their risk algorithm. I will have the results back from my biopsies (nodule and nodes) in the next several days. I am very happy to find this group for support and additional information sharing - it's hard to take it one day at a time, try not to meltdown emotionally, and helpful to not be "alone."

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@peg1224 UPDATE

I have been diagnosed with Low-grade B-cell lymphoproliferative disorder with lymphoplasmacytic differentiation.

Currently, my differential diagnosis includes marginal zone lymphoma with lymphoplasmacytic differentiation, and lymphoplasmacytic lymphoma; possibly LPL Waldenström's macroglobulinemia. The pulmonologists are transferring my care to a heme-oncologist and I will have additional tests to determine MYD88 status, a low grade B-cell lymphoma FISH panel and blood and urine protein electrophoresis and immunofixation tests.

I'll migrate my group membership to a specialty lymphoma group after this post - but it IS possible to have a nodule that initially looks like classic adenocarcinoma be diagnosed as something very different!

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Yes, it is possible I have had bronchiectasis for a few years and my last CT showed a nodule that is spiculated. Had a bronchoscopy four weeks ago and the biopsy result came back negative for cancer and shows that I have a microbacteria infection that is treatable with antibiotics. My pulmonologist referred me to an infectious disease specialist for treatment. Hope all comes out well for you.

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Profile picture for sunbeam1951 @sunbeam1951

Yes, it is possible I have had bronchiectasis for a few years and my last CT showed a nodule that is spiculated. Had a bronchoscopy four weeks ago and the biopsy result came back negative for cancer and shows that I have a microbacteria infection that is treatable with antibiotics. My pulmonologist referred me to an infectious disease specialist for treatment. Hope all comes out well for you.

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@sunbeam1951 Can you tell us a little about your symptoms?
Before finding the infection, did the pulmonologist have you doing airway clearance, with or without saline nebs to clear your lungs? Did they tell you how severe your infection is, like whether your lungs have cavities, and which strain(s) of mycobacteria were found?

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