Rising Ca19-9 and elevated Alkaline phosphatase

My husband just finished his 5th session of Gem/Abraxane. This is his second line treatment. He did 11 rounds of fulfirinox before it stopped working. His Ca19-9 has just continued to go up with this new chemo: 143 to 265 to 423-and now 719. A month ago his alk phos was 95 and then now it is 165, which I know isn't horrible. It had been going down and then shot back up this time. He has also mentioned a few times that his bones hurt which we had been assuming was from the new chemo. Now with everything combined, I am worried that this new chemo isn't working. I have message into oncologist to see about getting scan done sooner, as right now they don't have one planned until June 18th. I am just extremely concerned. He for the most part is still doing really good. He is active and eating fine (other than chemo day and day after). He has maintained his weight although I feel like he is quite a bit thinner (he has always been a bigger guy) and his pants are practically falling off. The oncologist never seems worried but makes us feel like there is no hope at the same time. We are also seeing oncologist at Mayo Rochester and go back at the end of this month. Thank you for listening to me vent my concerns. It helps to be able to tell people who understand what I am going through.