Did your mother take Diethylstilbestrol (DES) while pregnant with you?
I am a DES baby, which means my mother took the drug Diethylstilbestrol (DES) while pregnant with me.
DES was prescribed to prevent miscarriage from 1938-1971 in the US. (1977 in some other countries.) A 1953 US study proved it did not prevent miscarriage but did cause cancer in the mothers and a slew of problems for the babies in utero, including.......premature births, infertility, cancer, severe depression........the list goes on.
Because DES was developed in a public lab, any pharmaceutical company could manufacture it. They all profited greatly and thus continued promoting it regardless of the 1953 study.
It was also prescribed for morning sickness. (And possibly to dry milk? I'm not sure about that. Someone else may know.)
I would love to hear from other DES babies. I had many female problems over the years. I was able to have children, but it was a long road. I also suffered depression throughout my life and have now been diagnosed with an autoimmune disease.
I am wondering if any other women whose mothers or grandmothers took DES have suffered with severe depression and/or have developed the autoimmune disease, Polymyalgia Rheumatica?
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@luftmensh1 Thank you for reaching out. I probably was not DES. The story of DES began in 1938, when British physician and chemist Sir Charles Dodds and his team of scientists synthesized DES from a coal-tar derivative. DES, the first synthetic oral form of estrogen, mimicked the effect of natural estrogen. In the early 1940s it was being studied in the animal model.
I am sorry to hear of your problems and loss of your son.
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1 Reaction@heatherjm Thank you for sharing. DES was administered to some women via injections. DES caused a myriad of problems including depression.
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1 ReactionWow, am I glad to find this thread. I am a DES baby, as was my younger sister who died at age 49. I suffered a lot of depression until after menopause, but I am from a long line of that, so I don't know that that's a DES factor for me. I do know that both my sister and I wanted to have children and were not able to. We both got a late start, and that may be a factor, too. My mother's doctor did not want to prescribe DES but she campaigned for it, having had two miscarriages and wanting desperately to have children. She did not take DES with my two younger siblings, a sister and brother.
I had no idea that DES was a factor in infertility, and no gynecologist mentioned it, though several gasped when they looked into the speculum and I explained to them what they were seeing. I believed going into my 40s that I would, finally have children. Same with my sister who did artificial insemination and lost the fetus in the first trimester.
I am a writer trying to write more about this, have published one poem, have interview one friend with one son and an amazing story of two doctors in an O.S. U. clinic.
I look forward to reading more here.
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1 Reaction@sophie46
Gasp! What a story. A hug from here too.
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1 Reaction@dianekendig
fwiw, I forgot to say that I was born 1950, my sister 1952.
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1 Reaction@dianekendig
Sending a hug to you too. It is very sad that your sister died. You must miss her.
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1 Reaction@dianekendig DES Info Association would like to hear from you and your story. I am also a DES Daughter, dealing now with significant spine issues. It is a never-ending tragedy.
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1 ReactionAn Excerpt from the publication "VOICES OF THE DES-EXPOSED
SPEAKING OUT 2026"
Born in 1953: DES Daughter and my son is a miracle baby - my water broke 6 weeks early and my cervix went from 1 to 10 in half an hour. He weighed 4.5 pounds but is a healthy six-footer now. I had two ectopic pregnancies after his birth.
DES Daughter: I had endometriosis by the time I was 15 all the way up until menopause. Hundreds of fibroids removed from uterus on several occasions. I was born, I live, I love life, even with all the HORRENDOUS pain, and it was painful. Endometriosis is excruciating.
DES Daughter: I have had breast cancer & I carry the gene that can be passed on to my granddaughters.
Born in 1966: My mom had full uterine cancer just 3 mos. after I was born. She then had 9 different cancers in her lifetime.
Born in 1956: Breast cancer, multiple vague autoimmune conditions. Extra-long fallopian tubes - endometriosis. I was very fortunate to have a child after a miscarriage.