Did your mother take Diethylstilbestrol (DES) while pregnant with you?

Posted by cyndiefromnc @cyndiefromnc, Sep 6, 2025

I am a DES baby, which means my mother took the drug Diethylstilbestrol (DES) while pregnant with me.

DES was prescribed to prevent miscarriage from 1938-1971 in the US. (1977 in some other countries.) A 1953 US study proved it did not prevent miscarriage but did cause cancer in the mothers and a slew of problems for the babies in utero, including.......premature births, infertility, cancer, severe depression........the list goes on.

Because DES was developed in a public lab, any pharmaceutical company could manufacture it. They all profited greatly and thus continued promoting it regardless of the 1953 study.

It was also prescribed for morning sickness. (And possibly to dry milk? I'm not sure about that. Someone else may know.)

I would love to hear from other DES babies. I had many female problems over the years. I was able to have children, but it was a long road. I also suffered depression throughout my life and have now been diagnosed with an autoimmune disease.

I am wondering if any other women whose mothers or grandmothers took DES have suffered with severe depression and/or have developed the autoimmune disease, Polymyalgia Rheumatica?

Interested in more discussions like this? Go to the Women's Health Support Group.

Profile picture for luftmensh1 @luftmensh1

My mother, who was a maternity nurse, had several miscarriages/stillbirths before me. When she became pregnant with me in 1937 (I was born June 27, 1938), her doctor (Dr. Levine, I believe), told her he was going to give her something new that could help. What was it? It might have been DES, because that was new at the time. Although someone at NIH said it wasn't available to the general public at that time, I think that a doctor could have requested it. I have seen some other documentation that stated it was not limited to the "beginning in 1938" time frame. I have wondered about that, because I have had problems with anxiety and depression that began in my teen years. Also, one of my sons had an episode in which an immaturity of the nervous system caused him to stop breathing briefly as an infant due to a slight fever. The same son died at the age of 27 of lung cancer that metastasized to the brain and was inoperable, so I often wonder about this. It was about 6 months from diagnosis to his death.

Jump to this post

@luftmensh1 Thank you for reaching out. I probably was not DES. The story of DES began in 1938, when British physician and chemist Sir Charles Dodds and his team of scientists synthesized DES from a coal-tar derivative. DES, the first synthetic oral form of estrogen, mimicked the effect of natural estrogen. In the early 1940s it was being studied in the animal model.

I am sorry to hear of your problems and loss of your son.

REPLY
Profile picture for heatherjm @heatherjm

My mother had 2 or 3 DES injections in 1959 when pregnant with my younger sister, due to one previous miscarriage. Yes, only one prior miscarriage! Certainly not necessary for that drug intervention! I don't know when in the pregnancy she had them, but they weren't given from any miscarriage symptoms in the pregnancy. She can't remember exactly how many injections, and tried to get her medical records about them, but they weren't available. Probably because too long ago.
My sister had severe PMS, including rage, and weight gain from age 15. She was physically violent with me (not sure if that was only premenstrually), and her psychiatrist put in a mental health facility for a few months in her teen years. She was on the Pill on and off also, which could have made things worse.
She's had precancerous cells on her cervix, and one symptom that isn't being mentioned here, a problem with her son in utero sitting too high in her womb, jammed under her ribs. This resulted in a boney ridge on her son's forehead, and he had surgery on it when he was a baby.
DES can cause a triangle shaped uterus. So her baby didn't have enough room.
I told mum about this, but not my sister (I wasn't speaking to her at the time). Mum said, Don't tell Glenda (sister) due to her temper, as mum was worried Glenda would verbally abuse her and blame her. The whole family knew of her temper and occasional violence. I told Glenda after mum died.
My sister's teen son has anxiety and low self esteem. I can't get along with my sister, as she has like a split personality, nice for awhile, then nasty, critical, and is narcissistic at times. She's 67 now. I haven't heard of any other health problems, but we became estranged again in 2017, after her verbal abuse. Her weight stabilized in her 30s. I think that was after going off the Pill.
I've had to totally cease communicating with her for the final time for my own emotional wellbeing.

Jump to this post

@heatherjm Thank you for sharing. DES was administered to some women via injections. DES caused a myriad of problems including depression.

REPLY

Wow, am I glad to find this thread. I am a DES baby, as was my younger sister who died at age 49. I suffered a lot of depression until after menopause, but I am from a long line of that, so I don't know that that's a DES factor for me. I do know that both my sister and I wanted to have children and were not able to. We both got a late start, and that may be a factor, too. My mother's doctor did not want to prescribe DES but she campaigned for it, having had two miscarriages and wanting desperately to have children. She did not take DES with my two younger siblings, a sister and brother.
I had no idea that DES was a factor in infertility, and no gynecologist mentioned it, though several gasped when they looked into the speculum and I explained to them what they were seeing. I believed going into my 40s that I would, finally have children. Same with my sister who did artificial insemination and lost the fetus in the first trimester.
I am a writer trying to write more about this, have published one poem, have interview one friend with one son and an amazing story of two doctors in an O.S. U. clinic.
I look forward to reading more here.

REPLY
Profile picture for Sophie46 @sophie46

My mother had two miscarriages and when she started to lose me she was hospitalized. She was injected with DES each day for a week. At the age of forty she gave birth to me.

Jump to this post

@sophie46
Gasp! What a story. A hug from here too.

REPLY
Profile picture for dianekendig @dianekendig

Wow, am I glad to find this thread. I am a DES baby, as was my younger sister who died at age 49. I suffered a lot of depression until after menopause, but I am from a long line of that, so I don't know that that's a DES factor for me. I do know that both my sister and I wanted to have children and were not able to. We both got a late start, and that may be a factor, too. My mother's doctor did not want to prescribe DES but she campaigned for it, having had two miscarriages and wanting desperately to have children. She did not take DES with my two younger siblings, a sister and brother.
I had no idea that DES was a factor in infertility, and no gynecologist mentioned it, though several gasped when they looked into the speculum and I explained to them what they were seeing. I believed going into my 40s that I would, finally have children. Same with my sister who did artificial insemination and lost the fetus in the first trimester.
I am a writer trying to write more about this, have published one poem, have interview one friend with one son and an amazing story of two doctors in an O.S. U. clinic.
I look forward to reading more here.

Jump to this post

@dianekendig
fwiw, I forgot to say that I was born 1950, my sister 1952.

REPLY
Profile picture for dianekendig @dianekendig

@sophie46
Gasp! What a story. A hug from here too.

Jump to this post

@dianekendig
Sending a hug to you too. It is very sad that your sister died. You must miss her.

REPLY
Profile picture for dianekendig @dianekendig

Wow, am I glad to find this thread. I am a DES baby, as was my younger sister who died at age 49. I suffered a lot of depression until after menopause, but I am from a long line of that, so I don't know that that's a DES factor for me. I do know that both my sister and I wanted to have children and were not able to. We both got a late start, and that may be a factor, too. My mother's doctor did not want to prescribe DES but she campaigned for it, having had two miscarriages and wanting desperately to have children. She did not take DES with my two younger siblings, a sister and brother.
I had no idea that DES was a factor in infertility, and no gynecologist mentioned it, though several gasped when they looked into the speculum and I explained to them what they were seeing. I believed going into my 40s that I would, finally have children. Same with my sister who did artificial insemination and lost the fetus in the first trimester.
I am a writer trying to write more about this, have published one poem, have interview one friend with one son and an amazing story of two doctors in an O.S. U. clinic.
I look forward to reading more here.

Jump to this post

@dianekendig DES Info Association would like to hear from you and your story. I am also a DES Daughter, dealing now with significant spine issues. It is a never-ending tragedy.

REPLY

An Excerpt from the publication "VOICES OF THE DES-EXPOSED
SPEAKING OUT 2026"

Born in 1953: DES Daughter and my son is a miracle baby - my water broke 6 weeks early and my cervix went from 1 to 10 in half an hour. He weighed 4.5 pounds but is a healthy six-footer now. I had two ectopic pregnancies after his birth.

DES Daughter: I had endometriosis by the time I was 15 all the way up until menopause. Hundreds of fibroids removed from uterus on several occasions. I was born, I live, I love life, even with all the HORRENDOUS pain, and it was painful. Endometriosis is excruciating.

DES Daughter: I have had breast cancer & I carry the gene that can be passed on to my granddaughters.

Born in 1966: My mom had full uterine cancer just 3 mos. after I was born. She then had 9 different cancers in her lifetime.

Born in 1956: Breast cancer, multiple vague autoimmune conditions. Extra-long fallopian tubes - endometriosis. I was very fortunate to have a child after a miscarriage.

REPLY
Please sign in or register to post a reply.