Myrbetriq for overactive bladder.

Myrbetriq made little difference in nocturia, with my getting up 4-5 times nightly. I'm now taking Oxybutynin 5 mg twice daily and .4mg Tamsulosin at night, but no difference. I've also taken Afluzosin and Terazosin, same outcomes. Once I recover a bit after finishing my series of Orgovyx next month, I'll talk with my urologist about options for something invasive to help.

@narus
" I stopped taking it only to realize it was not doing all that much anyway "
I've been diagnosed with an overactive bladder and was prescribed Mybertriq. I quit taking it after a month because i felt it did nothing for me also.

The patent for Mybertriq is owned by the Japanese company Astellas Pharma Inc and is manufactured in Ireland and Japan. When last I tried to refill it at CVS the price was like $1400 with me contributing $400 for a 90 day supply of 25mg extended release so that is over $15/pill even if my cost is only $4.50 / pill. I live an hour south of Montreal and I have driven up there and refilled it for $300 without insurance.
Every Urologists I have seen is pushing the stuff and it is not worth the money even if someone else is paying. Classic example of the drug company bleeding patients for every penny they can.
Sorry for ranting.

@narus Sorry to here you are exploited by the pharmacy companies. Here in Panama mirabegron 50mg is available with the brand name of Urgistat, It is made in Argentina. Cost $1.00 a tablet or $90 for a 90 day supply.

Spent a lot of time in Argentina in the 90's doing survey work on The Total oil field off Tierra del Fuego. Argentina is defiantly one of my favorite places I have been. I remember at the time you needed no prescription for most products at the pharmacy. Was in Panama about 5 years ago after going thru the canal on the way to Guam.
Amazon now has a pharmacy and there prices are pretty fair. A prescription for Tamsulosin at CVS is $220 without insurance and $19.95 at Amazon. So why are insurance companies paying CVS $220 to fill a $20 prescription.
I can probably find mirabegron from some international pharmacy but the stuff just did not help all that much anyway and most of my issues resolved with time.

@narus My insurance claims to pay $14.90 for 90 days ($$ to calculate copay) of Tamsulosin. I can buy with discount coupon for $12.55 so I expect insurance cost is less with rebates. Same coupon at CVS was $21.09. Gemtesa is $243 per month and Mounjaro is $359, both far below any coupon cash price in USA but total price my copay is based on (actual cost could be lower). The USA has by far the highest drug prices in the world. Same problem exists for US medical care patients without insurance get ripped off with high list prices that are 3 to 4 times commercial insurance rates and about 8 times what Medicare pays. Amazon reserves the good prices for Prime members.

I recently became curious about Myrbetriq (Mirabegron) after hearing a presentation where a researcher talked very positively about it. I haven't thought about it very much, although I did notice a few things:

The Mayo Clinic has a webpage up that has a list, under a headline "Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines". The list contained Orgovyx (Relugolix).

A research paper pointed to by the guy who first drew my attention to this drug stated that the drug is indicated for the symptoms of BPH, i.e. overactive bladder (OAB). Perhaps not necessarily OAB due to external beam therapy? The drug was said to have less side effects than whatever is traditionally used, for OAB associated with BPH. The paper examined how good this drug was when used in combination with tamsulosin compared to tamsulosin by itself.

"In conclusion, compared to tamsulosin monotherapy, combination therapy with mirabegron 50 mg and tamsulosin 0.4 mg significantly improves LUTS in patients with BPH, particularly storage symptoms, without increasing adverse events. This combination therapy represents a promising treatment option." https://pubmed.ncbi.nlm.nih.gov/40759594/

More than 10% of patients taking this experience higher blood pressure. The list of side effects that could cause someone to quit in disgust seemed long....

@climateguy
Myrbetriq has worked well for me to stop the nightly urges to pee when I already emptied my bladder. I went from three or four times feeling urgency at night to going through all night without having to get up at all, Except on occasion one trip.

My blood pressure has been pretty low, So that hasn’t been a problem. I don’t take either of those other two drugs.

@jeffmarc The researcher I heard speak about it was saying similar things. That's why I became interested in it. I'm presently at 3 times a night, and I would really appreciate getting down to zero or one. I've heard some say the most important thing in cancer treatment is getting good sleep, and enough of it.

I'm presently preoccupied with getting ready to live in the big city for 20 treatments of external beam and how to have good bowel prep for it. It begins in a few days.

@climateguy
For many years, I always pooped in the morning right after getting up. That made the radiation no problem. You might be able to train your body by holding it until the morning. That’s not always possible, of course.