Myrbetriq for overactive bladder.

I’ve been on it for a couple of years and I’ve had no side effects at all.

There is another drug you can try. Ask your doctor about gemtesa

I used Gemtesa and it fixed my bladder problems over a few months. Was able to reduce dose and stop after 5 months. Same beta3 action as Myrbetriq. If that does not work there is also Tolterodine ER or Oxybutynin ER both low cost generics. These are smooth muscle receptor antagonist that acts on bladder to relax muscles thereby expanding capacity. Your doctor can recommend a few more if these do not work.

I used Myrbetriq for a couple months post surgery (2023). I could not discern any side effects or benefits from it, though I hope it works for others. My bladder control developed from Kegel exercises (for maybe 3 or 4 months) and cutting back on beer and caffeine (temporarily). Still, it was a long time before I could go without a pad.

I used myrbetriq with no side effects, it helped some. Then used Gemtesa it helped a little more. Both cost me $$ insurance would not cover, and I wanted more results so went in an talked to doctor about Botox injections in bladder, he told me about axonics implant and it is one and done deal, no going in every six months for more Botox. I am happy with the axonics simple surgery very short recovery time very minimal pain. But good results.

Recently, I used Myrbetriq for three months, and it did not improve my OAB symptoms in any way. However, it also did not cause any noticeable side effects. The potential side effect I was most concerned about was increased blood pressure, but fortunately, I did not experience that either.

No Myrbetriq side effects for me during the ~11 months I was on it in 2023–24 (at a double dose), but we all react differently. I'm sorry it was rough for you.

I had an extreme frequency problem after my RP. My doctor made a list of treatments in order of invasiveness. First on the list were medications, which didn't help. Second was SANS (Stoller Afferent Nerve Stimulation). It involves putting an acupuncture needle in your ankle which is attached to a battery, for 30 minutes. It stimulates a nerve that runs from the ankle to the bladder. Several weekly treatments are needed for results, followed by several monthly treatments. For me, it really worked with no side effects. I was lucky...I am a UCSF patient and saw Dr. Stoller who invented the procedure..but it's performed at many institutions now and there are even home kits available if you don't mind sticking yourself with an acupuncture needle. The more invasive treatments on the list were Botox injections and implanted devices. I didn't need those because the Stoller treatment worked so well (your results may vary).

@soli The regular 25mg dose of Myrbetriq did nothing for me either back in 2023, but when my urology oncologist doubled it to 50mg, the improvement was fast and dramatic: I went from waking every 30 min to urinate to getting up, at most, 2–3 times in the night.