Orgovyx extreme fatigue side effects

@jeffmarc "One thing that helps defeat the fatigue is exercise."

That sounds like a contradiction, but it's true.

When I went on Lupron 4.5 years ago, the effect was gradual over six months & mostly ignored. I attributed it to just getting older, but kept active, including a house move, so it wasn't a problem. Then two years ago I went off Lupron. Again, the effect was gradual & ignored.

Two months ago I went on Orgovyx. My testosterone dropped from over 600 to 18 in 12 days. Suddenly I felt the "fatigue". However, when I did my normal activities (mowing lawn, 1.5 mile brisk walks, repeatedly going up/down stairs, etc), I noticed no difference at the end. But sitting around, I felt "fatigued," particularly in the evening.

This leads me to believe that the sensation of fatigue is not imaginary, but rather "virtual."

I do notice that hot flashes are more numerous with Orgovyx. With Lupron, it was about once a week. Now, it's a couple times a day. It's annoying but tolerable.

Remember, it's NEVER going to be like it was before. It's "the new you." If you don't adapt, you'll feel miserable.

@jeffmarc
They are testing 2 new medications. They are receptor blockers for PSA

@jeffmarc "One thing that helps defeat the fatigue is exercise."

That sounds like a contradiction, but it's true.

When I went on Lupron 4.5 years ago, the effect was gradual over six months & mostly ignored. I attributed it to just getting older, but kept active, including a house move, so it wasn't a problem. Then two years ago I went off Lupron. Again, the effect was gradual & ignored.

Two months ago I went on Orgovyx. My testosterone dropped from over 600 to 18 in 12 days. Suddenly I felt the "fatigue". However, when I did my normal activities (mowing lawn, 1.5 mile brisk walks, repeatedly going up/down stairs, etc), I noticed no difference at the end. But sitting around, I felt "fatigued," particularly in the evening.

This leads me to believe that the sensation of fatigue is not imaginary, but rather "virtual."

I do notice that hot flashes are more numerous with Orgovyx. With Lupron, it was about once a week. Now, it's a couple times a day. It's annoying but tolerable.

Remember, it's NEVER going to be like it was before. It's "the new you." If you don't adapt, you'll feel miserable.

@readandlearn
Again, everyone is different shows up,’ I definitely have fewer hot flashes with Orgovyx.

At least yours aren’t too aggressive, A couple of times a day is definitely manageable.

@readandlearn
Thanks. He does do some exercising. He mows the lawn and works on the lawn. He's not consistent though. I think a lot or some has to do with his age. He is 73.

After some research of all his meds, we think it is his metoporol. He switched to replace the coreg he was on for his a-fib. The trial wasn't sure how the coreg would react with the trial drugs. He has an appointment to discuss switching it. Hopefully it will help. Thank you all for your replies.

So my question to you is this. Why do you keep continuing to use that medicine when it ties you out completely. I also have prostate cancer but I agree to have radiation therapy treatments and my problem went away and now I don't have the tiredness the fullness of my bladder or even wanting to go is bad. So why don't you try this getting your doctor to discontinue the use of it and try something else.

@tracey04141974 I took Metoprolol temporarily, but it caused a lot of dizziness, so much so that I had to be careful about driving, or even bending down or getting in/out of bed. I'm now on Diltiazem for BP control and Eliquis to manage against clotting with occasional Afib. Drug interactions can be frustrating!